(R)-N-[1-(3,5-di-tert-butylphenyl)-2-(1-piperidino)ethyl]trifluoroacetamide

Base Information

Chemical Name:(R)-N-[1-(3,5-di-tert-butylphenyl)-2-(1-piperidino)ethyl]trifluoroacetamide
CAS No.:338731-81-0
Molecular Formula:C₂₃H₃₅F₃N₂O
Molecular Weight:412.539
Hs Code.:

Synonyms:(R)-N-[1-(3,5-di-tert-butylphenyl)-2-(1-piperidino)ethyl]trifluoroacetamide

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Chemical Property of (R)-N-[1-(3,5-di-tert-butylphenyl)-2-(1-piperidino)ethyl]trifluoroacetamide

Chemical Property:

Purity/Quality:

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Technology Process of (R)-N-[1-(3,5-di-tert-butylphenyl)-2-(1-piperidino)ethyl]trifluoroacetamide

There total 4 articles about (R)-N-[1-(3,5-di-tert-butylphenyl)-2-(1-piperidino)ethyl]trifluoroacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 383-63-1
ethyl trifluoroacetate,

: 338731-80-9
(R)-1-(3,5-di-tert-butylphenyl)-2-(1-piperidino)ethylamine

: 338731-81-0
(R)-N-[1-(3,5-di-tert-butylphenyl)-2-(1-piperidino)ethyl]trifluoroacetamide

Guidance literature:: In methanol; at 20 ℃; for 4h;
DOI:10.1248/cpb.49.330

Reference yield:

: 142950-82-1
(R)-(-)-1-(2-amino-2-phenylethyl)piperidine

: 338731-81-0
(R)-N-[1-(3,5-di-tert-butylphenyl)-2-(1-piperidino)ethyl]trifluoroacetamide

Guidance literature:: Multi-step reaction with 4 steps

1: 75 percent / acetic acid / 2.5 h / Heating

2: 36 percent / AlCl₃ / 1 h

3: hydrazine hydrate / ethanol / 1.5 h / Heating

4: 77 percent / methanol / 4 h / 20 °C

With aluminium trichloride; hydrazine hydrate; In methanol; ethanol; acetic acid;
DOI:10.1248/cpb.49.330

Reference yield:

: 338731-78-5
(R)-N-phthaloyl-1-phenyl-2-(1-piperidino)ethylamine

: 338731-81-0
(R)-N-[1-(3,5-di-tert-butylphenyl)-2-(1-piperidino)ethyl]trifluoroacetamide

Guidance literature:: Multi-step reaction with 3 steps

1: 36 percent / AlCl₃ / 1 h

2: hydrazine hydrate / ethanol / 1.5 h / Heating

3: 77 percent / methanol / 4 h / 20 °C

With aluminium trichloride; hydrazine hydrate; In methanol; ethanol;
DOI:10.1248/cpb.49.330