3-((2R,4S)-2-(((tert-butoxycarbonyl)((R)-1-(naphthalen-1-yl)ethyl)amino)methyl)chroman-4-yl)-2,6-dimethylbenzoic acid

Base Information

Chemical Name:3-((2R,4S)-2-(((tert-butoxycarbonyl)((R)-1-(naphthalen-1-yl)ethyl)amino)methyl)chroman-4-yl)-2,6-dimethylbenzoic acid
CAS No.:1451374-85-8
Molecular Formula:C₃₆H₃₉NO₅
Molecular Weight:565.709
Hs Code.:

Synonyms:3-((2R,4S)-2-(((tert-butoxycarbonyl)((R)-1-(naphthalen-1-yl)ethyl)amino)methyl)chroman-4-yl)-2,6-dimethylbenzoic acid

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Chemical Property of 3-((2R,4S)-2-(((tert-butoxycarbonyl)((R)-1-(naphthalen-1-yl)ethyl)amino)methyl)chroman-4-yl)-2,6-dimethylbenzoic acid

Chemical Property:

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Technology Process of 3-((2R,4S)-2-(((tert-butoxycarbonyl)((R)-1-(naphthalen-1-yl)ethyl)amino)methyl)chroman-4-yl)-2,6-dimethylbenzoic acid

There total 15 articles about 3-((2R,4S)-2-(((tert-butoxycarbonyl)((R)-1-(naphthalen-1-yl)ethyl)amino)methyl)chroman-4-yl)-2,6-dimethylbenzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 3-((2R)-2-(((tert-butoxycarbonyl)((R)-1-(naphthalen-1-yl)ethyl)amino)methyl)chroman-4-yl)-2,6-dimethylbenzoic acid

: 1451374-85-8
3-((2R,4S)-2-(((tert-butoxycarbonyl)((R)-1-(naphthalen-1-yl)ethyl)amino)methyl)chroman-4-yl)-2,6-dimethylbenzoic acid

Guidance literature:: With trifluoroacetic acid; In hexane; isopropyl alcohol;

Reference yield:

: C₄₃H₄₃NO₅

: 1451374-85-8
3-((2R,4S)-2-(((tert-butoxycarbonyl)((R)-1-(naphthalen-1-yl)ethyl)amino)methyl)chroman-4-yl)-2,6-dimethylbenzoic acid

: 3-((2R,4S)-2-(((tert-butoxycarbonyl)((R)-1-(naphthalen-1-yl)ethyl)amino)methyl)chroman-4-yl)-2,6-dimethylbenzoic acid

Guidance literature:: With palladium 10% on activated carbon; hydrogen; In methanol;

Reference yield:

: 83780-47-6
(-)-(R)-3,4-dihydro-2H-1-benzopyran-2-carboxylic acid

: 1451374-85-8
3-((2R,4S)-2-(((tert-butoxycarbonyl)((R)-1-(naphthalen-1-yl)ethyl)amino)methyl)chroman-4-yl)-2,6-dimethylbenzoic acid

Guidance literature:: Multi-step reaction with 8 steps

1.1: thionyl chloride / 1,2-dichloro-ethane / 1 h / 0 - 20 °C / Reflux

1.3: 1 h / 0 °C

2.1: dimethylsulfide borane complex / tetrahydrofuran / 2 h / 0 - 70 °C

3.1: acetonitrile / 50 °C

4.1: magnesium sulfate; potassium permanganate / water; acetone / 16 h / 0 - 20 °C

5.1: potassium hexamethylsilazane / tetrahydrofuran / 1 h / -78 °C

5.2: -78 - 20 °C / Inert atmosphere

6.1: sodium carbonate / water; toluene; ethanol / 0.5 h / Inert atmosphere

6.2: 1 h / 65 °C / Inert atmosphere

7.1: palladium 10% on activated carbon; hydrogen / methanol

8.1: trifluoroacetic acid / hexane; isopropyl alcohol

With potassium permanganate; thionyl chloride; dimethylsulfide borane complex; palladium 10% on activated carbon; hydrogen; potassium hexamethylsilazane; sodium carbonate; magnesium sulfate; trifluoroacetic acid; In tetrahydrofuran; methanol; ethanol; hexane; water; 1,2-dichloro-ethane; isopropyl alcohol; acetone; toluene; acetonitrile;