2,6-dimethyl-3-((2R,4S)-2-((((R)-1-(naphthalen-1-yl)ethyl)amino)methyl)chroman-4-yl)benzoic acid hydrochloride

Base Information

Chemical Name:2,6-dimethyl-3-((2R,4S)-2-((((R)-1-(naphthalen-1-yl)ethyl)amino)methyl)chroman-4-yl)benzoic acid hydrochloride
CAS No.:1451372-90-9
Molecular Formula:C₃₁H₃₁NO₃*ClH
Molecular Weight:502.053
Hs Code.:

Synonyms:2,6-dimethyl-3-((2R,4S)-2-((((R)-1-(naphthalen-1-yl)ethyl)amino)methyl)chroman-4-yl)benzoic acid hydrochloride

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Chemical Property of 2,6-dimethyl-3-((2R,4S)-2-((((R)-1-(naphthalen-1-yl)ethyl)amino)methyl)chroman-4-yl)benzoic acid hydrochloride

Chemical Property:

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Technology Process of 2,6-dimethyl-3-((2R,4S)-2-((((R)-1-(naphthalen-1-yl)ethyl)amino)methyl)chroman-4-yl)benzoic acid hydrochloride

There total 11 articles about 2,6-dimethyl-3-((2R,4S)-2-((((R)-1-(naphthalen-1-yl)ethyl)amino)methyl)chroman-4-yl)benzoic acid hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 1451374-85-8
3-((2R,4S)-2-(((tert-butoxycarbonyl)((R)-1-(naphthalen-1-yl)ethyl)amino)methyl)chroman-4-yl)-2,6-dimethylbenzoic acid

: 1451372-90-9
2,6-dimethyl-3-((2R,4S)-2-((((R)-1-(naphthalen-1-yl)ethyl)amino)methyl)chroman-4-yl)benzoic acid hydrochloride

Guidance literature:: With hydrogenchloride; In diethyl ether; dichloromethane; at 20 ℃;

Reference yield:

: 51939-71-0
chroman-2-carboxylic acid

: 1451372-90-9
2,6-dimethyl-3-((2R,4S)-2-((((R)-1-(naphthalen-1-yl)ethyl)amino)methyl)chroman-4-yl)benzoic acid hydrochloride

Guidance literature:: Multi-step reaction with 10 steps

1.1: 1-phenylpropylamine / acetonitrile; tert-butyl methyl ether / 6 h / 20 °C

1.2: 0 °C

2.1: thionyl chloride / 1,2-dichloro-ethane / 1 h / 0 - 20 °C / Reflux

2.3: 1 h / 0 °C

3.1: dimethylsulfide borane complex / tetrahydrofuran / 2 h / 0 - 70 °C

4.1: acetonitrile / 50 °C

5.1: magnesium sulfate; potassium permanganate / water; acetone / 16 h / 0 - 20 °C

6.1: potassium hexamethylsilazane / tetrahydrofuran / 1 h / -78 °C

6.2: -78 - 20 °C / Inert atmosphere

7.1: sodium carbonate / water; toluene; ethanol / 0.5 h / Inert atmosphere

7.2: 1 h / 65 °C / Inert atmosphere

8.1: palladium 10% on activated carbon; hydrogen / methanol

9.1: trifluoroacetic acid / hexane; isopropyl alcohol

10.1: hydrogenchloride / dichloromethane; diethyl ether / 20 °C

With hydrogenchloride; potassium permanganate; thionyl chloride; dimethylsulfide borane complex; palladium 10% on activated carbon; 1-phenylpropylamine; hydrogen; potassium hexamethylsilazane; sodium carbonate; magnesium sulfate; trifluoroacetic acid; In tetrahydrofuran; methanol; diethyl ether; ethanol; hexane; dichloromethane; tert-butyl methyl ether; water; 1,2-dichloro-ethane; isopropyl alcohol; acetone; toluene; acetonitrile;

Reference yield:

: 83780-47-6
(-)-(R)-3,4-dihydro-2H-1-benzopyran-2-carboxylic acid

: 1451372-90-9
2,6-dimethyl-3-((2R,4S)-2-((((R)-1-(naphthalen-1-yl)ethyl)amino)methyl)chroman-4-yl)benzoic acid hydrochloride

Guidance literature:: Multi-step reaction with 9 steps

1.1: thionyl chloride / 1,2-dichloro-ethane / 1 h / 0 - 20 °C / Reflux

1.3: 1 h / 0 °C

2.1: dimethylsulfide borane complex / tetrahydrofuran / 2 h / 0 - 70 °C

3.1: acetonitrile / 50 °C

4.1: magnesium sulfate; potassium permanganate / water; acetone / 16 h / 0 - 20 °C

5.1: potassium hexamethylsilazane / tetrahydrofuran / 1 h / -78 °C

5.2: -78 - 20 °C / Inert atmosphere

6.1: sodium carbonate / water; toluene; ethanol / 0.5 h / Inert atmosphere

6.2: 1 h / 65 °C / Inert atmosphere

7.1: palladium 10% on activated carbon; hydrogen / methanol

8.1: trifluoroacetic acid / hexane; isopropyl alcohol

9.1: hydrogenchloride / dichloromethane; diethyl ether / 20 °C

With hydrogenchloride; potassium permanganate; thionyl chloride; dimethylsulfide borane complex; palladium 10% on activated carbon; hydrogen; potassium hexamethylsilazane; sodium carbonate; magnesium sulfate; trifluoroacetic acid; In tetrahydrofuran; methanol; diethyl ether; ethanol; hexane; dichloromethane; water; 1,2-dichloro-ethane; isopropyl alcohol; acetone; toluene; acetonitrile;