biphenyl-2-yl-carbamic acid 1-{9-[(R)-2-(tert-butyldimethylsilanyloxy)-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethylamino]nonyl}piperidin-4-yl ester

Base Information

Chemical Name:biphenyl-2-yl-carbamic acid 1-{9-[(R)-2-(tert-butyldimethylsilanyloxy)-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethylamino]nonyl}piperidin-4-yl ester
CAS No.:743460-27-7
Molecular Formula:C₄₄H₆₂N₄O₅Si
Molecular Weight:755.086
Hs Code.:

biphenyl-2-yl-carbamic acid 1-{9-[(R)-2-(tert-butyldimethylsilanyloxy)-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethylamino]nonyl}piperidin-4-yl ester

Synonyms:biphenyl-2-yl-carbamic acid 1-{9-[(R)-2-(tert-butyldimethylsilanyloxy)-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethylamino]nonyl}piperidin-4-yl ester

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Chemical Property of biphenyl-2-yl-carbamic acid 1-{9-[(R)-2-(tert-butyldimethylsilanyloxy)-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethylamino]nonyl}piperidin-4-yl ester

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Technology Process of biphenyl-2-yl-carbamic acid 1-{9-[(R)-2-(tert-butyldimethylsilanyloxy)-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethylamino]nonyl}piperidin-4-yl ester

There total 5 articles about biphenyl-2-yl-carbamic acid 1-{9-[(R)-2-(tert-butyldimethylsilanyloxy)-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethylamino]nonyl}piperidin-4-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 852291-44-2
biphenyl-2-ylcarbamic acid 1-(9-hydroxynonyl)piperidin-4-yl ester

: 743460-27-7
biphenyl-2-yl-carbamic acid 1-{9-[(R)-2-(tert-butyldimethylsilanyloxy)-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethylamino]nonyl}piperidin-4-yl ester

Guidance literature:: Multi-step reaction with 2 steps

1: sulfur trioxide pyridine complex; dimethyl sulfoxide; N-ethyl-N,N-diisopropylamine / dichloromethane / 0 °C

2: sodium tris(acetoxy)borohydride / methanol; dichloromethane

With sulfur trioxide pyridine complex; sodium tris(acetoxy)borohydride; dimethyl sulfoxide; N-ethyl-N,N-diisopropylamine; In methanol; dichloromethane;
DOI:10.1016/j.bmcl.2011.01.043

Reference yield:

: 4727-72-4
1-benzyl-4-hydroxypiperidine

: 743460-27-7
biphenyl-2-yl-carbamic acid 1-{9-[(R)-2-(tert-butyldimethylsilanyloxy)-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethylamino]nonyl}piperidin-4-yl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 70 °C / neat (no solvent)

2: 10% palladium on activated charcoal; ammonium bicarbonate / ethanol / 40 °C

3: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 50 °C

4: sulfur trioxide pyridine complex; dimethyl sulfoxide; N-ethyl-N,N-diisopropylamine / dichloromethane / 0 °C

5: sodium tris(acetoxy)borohydride / methanol; dichloromethane

With 10% palladium on activated charcoal; sulfur trioxide pyridine complex; sodium tris(acetoxy)borohydride; ammonium bicarbonate; dimethyl sulfoxide; N-ethyl-N,N-diisopropylamine; In methanol; ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2011.01.043

Reference yield:

: 17337-13-2
[1,1'-biphenyl]-2-yl-isocyanate

: 743460-27-7
biphenyl-2-yl-carbamic acid 1-{9-[(R)-2-(tert-butyldimethylsilanyloxy)-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethylamino]nonyl}piperidin-4-yl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 70 °C / neat (no solvent)

2: 10% palladium on activated charcoal; ammonium bicarbonate / ethanol / 40 °C

3: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 50 °C

4: sulfur trioxide pyridine complex; dimethyl sulfoxide; N-ethyl-N,N-diisopropylamine / dichloromethane / 0 °C

5: sodium tris(acetoxy)borohydride / methanol; dichloromethane

With 10% palladium on activated charcoal; sulfur trioxide pyridine complex; sodium tris(acetoxy)borohydride; ammonium bicarbonate; dimethyl sulfoxide; N-ethyl-N,N-diisopropylamine; In methanol; ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2011.01.043