THRX-198321

Base Information

Chemical Name:THRX-198321
CAS No.:743460-20-0
Molecular Formula:C₃₈H₄₈N₄O₅
Molecular Weight:640.823
Hs Code.:

Synonyms:THRX-198321

Suppliers and Price of THRX-198321

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of THRX-198321

Chemical Property:

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Technology Process of THRX-198321

There total 8 articles about THRX-198321 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 743460-27-7
biphenyl-2-yl-carbamic acid 1-{9-[(R)-2-(tert-butyldimethylsilanyloxy)-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethylamino]nonyl}piperidin-4-yl ester

: 743460-20-0
THRX-198321

Guidance literature:: With triethylamine tris(hydrogen fluoride); In dichloromethane; for 18 - 20h;

Reference yield:

: 743460-27-7
biphenyl-2-yl-carbamic acid 1-{9-[(R)-2-(tert-butyldimethylsilanyloxy)-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethylamino]nonyl}piperidin-4-yl ester

: 73602-61-6,23588-89-8,29585-72-6,94527-74-9
triethylamine tris(hydrogen fluoride)

: 743460-20-0
THRX-198321

Guidance literature:: In dichloromethane; for 18 - 20h;

Reference yield:

: 852291-44-2
biphenyl-2-ylcarbamic acid 1-(9-hydroxynonyl)piperidin-4-yl ester

: 743460-20-0
THRX-198321

Guidance literature:: Multi-step reaction with 3 steps

1: sulfur trioxide pyridine complex; dimethyl sulfoxide; N-ethyl-N,N-diisopropylamine / dichloromethane / 0 °C

2: sodium tris(acetoxy)borohydride / methanol; dichloromethane

3: triethylamine tris(hydrogen fluoride) / dichloromethane; N,N-dimethyl-formamide

With sulfur trioxide pyridine complex; sodium tris(acetoxy)borohydride; dimethyl sulfoxide; triethylamine tris(hydrogen fluoride); N-ethyl-N,N-diisopropylamine; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2011.01.043