3-[{3-[(5-bromopentyl)(2-nitrobenzenesulfonyl)amino]propyl}(2-nitrobenzenesulfonyl)amino]-N-[3-(2-nitrobenzenesulfonylamino)propyl]butyramide

Base Information

Chemical Name:3-[{3-[(5-bromopentyl)(2-nitrobenzenesulfonyl)amino]propyl}(2-nitrobenzenesulfonyl)amino]-N-[3-(2-nitrobenzenesulfonylamino)propyl]butyramide
CAS No.:318466-85-2
Molecular Formula:C₃₃H₄₂BrN₇O₁₃S₃
Molecular Weight:920.838
Hs Code.:

3-[{3-[(5-bromopentyl)(2-nitrobenzenesulfonyl)amino]propyl}(2-nitrobenzenesulfonyl)amino]-N-[3-(2-nitrobenzenesulfonylamino)propyl]butyramide

Synonyms:3-[{3-[(5-bromopentyl)(2-nitrobenzenesulfonyl)amino]propyl}(2-nitrobenzenesulfonyl)amino]-N-[3-(2-nitrobenzenesulfonylamino)propyl]butyramide

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Chemical Property of 3-[{3-[(5-bromopentyl)(2-nitrobenzenesulfonyl)amino]propyl}(2-nitrobenzenesulfonyl)amino]-N-[3-(2-nitrobenzenesulfonylamino)propyl]butyramide

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Technology Process of 3-[{3-[(5-bromopentyl)(2-nitrobenzenesulfonyl)amino]propyl}(2-nitrobenzenesulfonyl)amino]-N-[3-(2-nitrobenzenesulfonylamino)propyl]butyramide

There total 7 articles about 3-[{3-[(5-bromopentyl)(2-nitrobenzenesulfonyl)amino]propyl}(2-nitrobenzenesulfonyl)amino]-N-[3-(2-nitrobenzenesulfonylamino)propyl]butyramide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 240423-09-0
N-(6-aminopropyl)-2-nitrobenzenesulfonamide

: 474886-89-0
3-[{3-[(5-bromopentyl)(2-nitrobenzenesulfonyl)amino]propyl}(2-nitrobenzenesulfonyl)amino]butyric acid

: 318466-85-2
3-[{3-[(5-bromopentyl)(2-nitrobenzenesulfonyl)amino]propyl}(2-nitrobenzenesulfonyl)amino]-N-[3-(2-nitrobenzenesulfonylamino)propyl]butyramide

Guidance literature:: With WSCD*HCl; In dichloromethane; at 20 ℃; for 0.5h;

Reference yield:

: 1694-92-4
2-Nitrobenzenesulfonyl chloride

: 318466-85-2
3-[{3-[(5-bromopentyl)(2-nitrobenzenesulfonyl)amino]propyl}(2-nitrobenzenesulfonyl)amino]-N-[3-(2-nitrobenzenesulfonylamino)propyl]butyramide

Guidance literature:: Multi-step reaction with 4 steps

1: 87 percent / triethylamine / CH₂Cl₂ / 0.5 h / 20 °C

2: 71 percent / Ph₃P; DEAD / benzene; toluene / 0.17 h / 20 °C

3: 784 mg / pyrrolidine / Pd(PPh₃)4 / CH₂Cl₂ / 0.5 h / 20 °C

4: 760 mg / EDCI / CH₂Cl₂ / 0.5 h / 20 °C

With pyrrolidine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; triphenylphosphine; diethylazodicarboxylate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In dichloromethane; toluene; benzene; 2: Mitsunobu reaction;
DOI:10.1016/S0040-4020(02)00626-9

Reference yield:

: 196214-23-0
N-(3-hydroxypropyl)-2-nitrobenzenesulfonamide

: 318466-85-2
3-[{3-[(5-bromopentyl)(2-nitrobenzenesulfonyl)amino]propyl}(2-nitrobenzenesulfonyl)amino]-N-[3-(2-nitrobenzenesulfonylamino)propyl]butyramide

Guidance literature:: Multi-step reaction with 4 steps

1: 85 percent / cesium carbonate / acetonitrile / 2 h / 60 °C

2: 71 percent / Ph₃P; DEAD / benzene; toluene / 0.17 h / 20 °C

3: 784 mg / pyrrolidine / Pd(PPh₃)4 / CH₂Cl₂ / 0.5 h / 20 °C

4: 760 mg / EDCI / CH₂Cl₂ / 0.5 h / 20 °C

With pyrrolidine; caesium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triphenylphosphine; diethylazodicarboxylate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In dichloromethane; toluene; acetonitrile; benzene; 2: Mitsunobu reaction;
DOI:10.1016/S0040-4020(02)00626-9