240423-09-0

Basic information

• Product Name: 1-AMINO-3-(2-NITROBENZENESULFONAMIDO)PROPANE
• Synonyms: N-(3-AMINOPROPYL)-2-NITROBENZENESULFONAMIDE;N-(2-NITROBENZENESULFONYL)-1,3-PROPANEDIAMINE;1-AMINO-3-(2-NITROBENZENESULFONAMIDO)PROPANE;1-Amino-3-(2-nitrobenzenesulfonamido)propane N-(2-Nitrobenzenesulfonyl)-1,3-propanediamine N-(o-Ns)-1,3-diaminopropane
• CAS NO: 240423-09-0
• Molecular Formula: C₉H₁₃N₃O₄S
• Molecular Weight: 259.28
• Product Categories: Monoprotected Diaminoalkanes;N-(o-Ns)-diaminoalkanes
• Mol File: 240423-09-0.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 448.997°C at 760 mmHg
• Flash Point: 225.346°C
• Appearance: /
• Density: 1.375g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.58
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• PKA: 9.18±0.40(Predicted)
• CAS DataBase Reference: 1-AMINO-3-(2-NITROBENZENESULFONAMIDO)PROPANE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-AMINO-3-(2-NITROBENZENESULFONAMIDO)PROPANE(240423-09-0)
• EPA Substance Registry System: 1-AMINO-3-(2-NITROBENZENESULFONAMIDO)PROPANE(240423-09-0)

Safety Data

• Hazardous Substances Data: 240423-09-0(Hazardous Substances Data)

Usage

General Description

1-AMINO-3-(2-NITROBENZENESULFONAMIDO)PROPANE is a chemical compound with the molecular formula C9H12N3O5S. It is an organic compound that contains an amino group and a nitrobenzenesulfonamido group. This chemical is commonly used as a building block in organic synthesis and pharmaceutical research. It has the potential to be a useful intermediate in the production of various pharmaceuticals. 1-AMINO-3-(2-NITROBENZENESULFONAMIDO)PROPANE is important in the development of new drugs and can also be used in the manufacturing of other chemical products.

InChI:InChI=1/C9H13N3O4S/c10-6-3-7-11-17(15,16)9-5-2-1-4-8(9)12(13)14/h1-2,4-5,11H,3,6-7,10H2

Upstream product

• 1694-92-4 2-Nitrobenzenesulfonyl chloride 
• 109-76-2 Trimethylenediamine 

Downstream Products

• 312283-45-7 N-(2-nitrobenzenesulfonyl)-N'-(allyloxycarbonyl)-1,3-diaminopropane 
• 312283-38-8 N-[3-(2-nitrobenzenesulfonyl)amino-propan-1-yl]-1H-indole-3-acetamide 
• 318466-89-6 3-[{3-[[5-(tert-butyldimethylsilanyloxy)pentyl](2-nitrobenzenesulfonyl)amino]propyl}(2-nitrobenzenesulfonyl)amino]-N-[3-(2-nitrobenzenesulfonylamino)propyl]butyramide 
• 318466-85-2 3-[{3-[(5-bromopentyl)(2-nitrobenzenesulfonyl)amino]propyl}(2-nitrobenzenesulfonyl)amino]-N-[3-(2-nitrobenzenesulfonylamino)propyl]butyramide 
• 240423-18-1 N-(tert-butoxycarbonyl)-N'-(2-nitrobenzenesulfonyl)-1,3-propanediamine 
• 437718-40-6 N-(2-nitrobenzenesulfonyl)-N'-(benzyloxycarbonyl)-1,3-diaminopropane 
• 1012064-13-9 N(12)-benzyloxycarbonyl-N(1)-[Nα,Nε-di(tert-butoxycarbonyl)lysyl]-4,8-di(2-nitrobenzenesulfonyl)-4,8-diaza-1,12-dodecanediamine 
• 1109218-14-5 C₁₆H₁₈N₄O₇S 
• 1048001-96-2 1-[(2-nitrophenyl)sulfonyl]-1,5,9-triazacyclododecane 
• 1048001-92-8 1-[(2-nitrophenyl)sulfonyl]-1,5-diazacyclooctane 
• 1048001-97-3 1-[(2-nitrophenyl)sulfonyl]-1,5,9,13-tetraazacyclohexadecane 
• 312283-49-1 N-[20-tert-butoxycarbonylamino-4-(2-cyanoethyl)-8,12,17-tris(2-nitrobenzenesulfonyl)-4,8,12,17-tetraazaicosan-1-yl]-1-tert-butoxycarbonyl-indole-3-acetamide 
• 312283-50-4 N-[20-tert-butoxycarbonylamino-4-hydroxy-8,12,17-tris(2-nitrobenzenesulfonyl)-4,8,12,17-tetraazaicosan-1-yl]-1-tert-butoxycarbonyl-indole-3-acetamide 
• 312283-51-5 N-(20-amino-4-hydroxy-8,12,17-tris(2-nitrobenzenesulfonyl)-4,8,12,17-tetraazaicosan-1-yl)-1H-indole-3-acetamide 

Relevant articles and documents

Heteroatom-embedded medium-sized cycloalkynes: Concise synthesis, structural analysis, and reactions

A variety of medium-sized cycloalkynes were efficiently synthesized by the double Nicholas reaction of cobalt complex and bis(hetero)substituted acyclic compound. The alkyne moiety within the ring has a unique bent structure and high reactivity toward cycloaddition reactions. Furthermore, preparation of multifunctionalized alkynes was achieved by embedding the cycloalkyne within a peptide chain.

Syntheses and biological activities of fluorescent-labeled analogs of acylpolyamine toxin NPTX-594 isolated from the venom of Madagascar Joro spider

Acylpolyamine-type spider toxins are known to be potent and specific blockers against glutamate receptors (GluRs). The present study describes the syntheses and biological activities of several fluorescent-labeled analogs related to a Madagascar Joro spider toxin NPTX-594 to analyze visually the unknown interaction between spider toxins and GluRs.

Synthesis of 3-substituted bicyclic imidazo[1,2-d][1,2,4]thiadiazoles and tricyclic benzo[4,5]imidazo[1,2-d][1,2,4]thiadiazoles

A versatile synthetic route to potentially useful fused-ring [1,2,4]thiadiazole scaffolds (e.g., 7a and 10b) via exchange reactions of the precursor [1,2,4]thiadiazol-3-(2H)one derivatives (e.g., 6 and 9) with appropriately substituted nitriles (e.g., cyanogen bromide or p-toluenesulfonyl cyanide) under mild conditions is described. For example, the tricyclic 3-bromo [1,2,4]THD derivative (7a) underwent SNAr substitution with a variety of nucleophiles, which included amines, malonate esters and alcohols. Likewise, the bicyclic 3-p-tosyl [1,2,4]THD (10b) was employed as a template in reaction with diamines, and the resulting substituted diamines (e.g., 12a or 12e) were further selectively derivatized at the N1 and/or N2 positions in a linear fashion. The X-ray crystal structure of the 3-methyl bicyclic [1,2,4]THD (21) was obtained, and selective methylation at the N1 position via a protection-alkylation-deprotection protocol, as illustrated in Scheme 6, was confirmed. Alternatively, a short convergent synthesis of N1-functionalized derivatives from the reaction of 10b with appropriately substituted secondary amines was also developed. Hence, these synthetic strategies were advantageously exploited to provide access to a variety of diversely derivatized 3-substituted fused-ring [1,2,4]thiadiazole derivatives.