1-methyl-5-[[[1(S)-[[[3,5-bis(benzyloxycarbonyl)phenyl]amino]carbonyl]-2-phenylethyl]amino]carbonyl]-6-[[(1-adamantylmethyl)amino]carbonyl]indole

Base Information

Chemical Name:1-methyl-5-[[[1(S)-[[[3,5-bis(benzyloxycarbonyl)phenyl]amino]carbonyl]-2-phenylethyl]amino]carbonyl]-6-[[(1-adamantylmethyl)amino]carbonyl]indole
CAS No.:167992-87-2
Molecular Formula:C₅₃H₅₂N₄O₇
Molecular Weight:857.018
Hs Code.:

Synonyms:1-methyl-5-[[[1(S)-[[[3,5-bis(benzyloxycarbonyl)phenyl]amino]carbonyl]-2-phenylethyl]amino]carbonyl]-6-[[(1-adamantylmethyl)amino]carbonyl]indole

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Chemical Property of 1-methyl-5-[[[1(S)-[[[3,5-bis(benzyloxycarbonyl)phenyl]amino]carbonyl]-2-phenylethyl]amino]carbonyl]-6-[[(1-adamantylmethyl)amino]carbonyl]indole

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Technology Process of 1-methyl-5-[[[1(S)-[[[3,5-bis(benzyloxycarbonyl)phenyl]amino]carbonyl]-2-phenylethyl]amino]carbonyl]-6-[[(1-adamantylmethyl)amino]carbonyl]indole

There total 5 articles about 1-methyl-5-[[[1(S)-[[[3,5-bis(benzyloxycarbonyl)phenyl]amino]carbonyl]-2-phenylethyl]amino]carbonyl]-6-[[(1-adamantylmethyl)amino]carbonyl]indole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.0%

: 167992-88-3
5-[(S)-2-({6-[(Adamantan-1-ylmethyl)-carbamoyl]-1H-indole-5-carbonyl}-amino)-3-phenyl-propionylamino]-isophthalic acid dibenzyl ester

: 74-88-4
methyl iodide

: 167992-87-2
1-methyl-5-[[[1(S)-[[[3,5-bis(benzyloxycarbonyl)phenyl]amino]carbonyl]-2-phenylethyl]amino]carbonyl]-6-[[(1-adamantylmethyl)amino]carbonyl]indole

Guidance literature:: With sodium hydride; In tetrahydrofuran; N,N-dimethyl-formamide; at 20 ℃; for 1h;
DOI:10.1021/jm0010668

Reference yield:

: 88330-43-2
1-methylindole-5,6-dicarboxylic acid

: 167992-87-2
1-methyl-5-[[[1(S)-[[[3,5-bis(benzyloxycarbonyl)phenyl]amino]carbonyl]-2-phenylethyl]amino]carbonyl]-6-[[(1-adamantylmethyl)amino]carbonyl]indole

Guidance literature:: Multi-step reaction with 2 steps

1.1: 92 percent / Ac₂O / 1 h / Heating

2.1: Et₃N / tetrahydrofuran / 0.08 h / Heating

2.2: PyBOP; diisopropylethylamine / CH₂Cl₂

With acetic anhydride; triethylamine; In tetrahydrofuran;
DOI:10.1021/jm0010668

Reference yield:

: 88330-42-1
dimethyl 1-methylindole-5,6-dicarboxylate

: 167992-87-2
1-methyl-5-[[[1(S)-[[[3,5-bis(benzyloxycarbonyl)phenyl]amino]carbonyl]-2-phenylethyl]amino]carbonyl]-6-[[(1-adamantylmethyl)amino]carbonyl]indole

Guidance literature:: Multi-step reaction with 3 steps

1.1: 98 percent / aq. NaOH / ethanol / 0.25 h / Heating

2.1: 92 percent / Ac₂O / 1 h / Heating

3.1: Et₃N / tetrahydrofuran / 0.08 h / Heating

3.2: PyBOP; diisopropylethylamine / CH₂Cl₂

With sodium hydroxide; acetic anhydride; triethylamine; In tetrahydrofuran; ethanol;
DOI:10.1021/jm0010668