2-((S)-1-{[2-((S)-1-Benzyloxycarbonylamino-2-methyl-propyl)-oxazole-4-carbonyl]-amino}-2-methyl-propyl)-thiazole-4-carboxylic acid ethyl ester

Base Information

Chemical Name:2-((S)-1-{[2-((S)-1-Benzyloxycarbonylamino-2-methyl-propyl)-oxazole-4-carbonyl]-amino}-2-methyl-propyl)-thiazole-4-carboxylic acid ethyl ester
CAS No.:220717-71-5
Molecular Formula:C₂₆H₃₂N₄O₆S
Molecular Weight:528.629
Hs Code.:

Synonyms:2-((S)-1-{[2-((S)-1-Benzyloxycarbonylamino-2-methyl-propyl)-oxazole-4-carbonyl]-amino}-2-methyl-propyl)-thiazole-4-carboxylic acid ethyl ester

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Chemical Property of 2-((S)-1-{[2-((S)-1-Benzyloxycarbonylamino-2-methyl-propyl)-oxazole-4-carbonyl]-amino}-2-methyl-propyl)-thiazole-4-carboxylic acid ethyl ester

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Technology Process of 2-((S)-1-{[2-((S)-1-Benzyloxycarbonylamino-2-methyl-propyl)-oxazole-4-carbonyl]-amino}-2-methyl-propyl)-thiazole-4-carboxylic acid ethyl ester

There total 9 articles about 2-((S)-1-{[2-((S)-1-Benzyloxycarbonylamino-2-methyl-propyl)-oxazole-4-carbonyl]-amino}-2-methyl-propyl)-thiazole-4-carboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 501-53-1,94274-21-2
benzyl chloroformate

: 220717-62-4
2-((S)-1-{[2-((S)-1-Amino-2-methyl-propyl)-oxazole-4-carbonyl]-amino}-2-methyl-propyl)-thiazole-4-carboxylic acid ethyl ester

: 220717-71-5
2-((S)-1-{[2-((S)-1-Benzyloxycarbonylamino-2-methyl-propyl)-oxazole-4-carbonyl]-amino}-2-methyl-propyl)-thiazole-4-carboxylic acid ethyl ester

Guidance literature:: With potassium carbonate; In methanol; dichloromethane; for 12h; Ambient temperature;
DOI:10.1021/jo981664i

Reference yield:

: 70-23-5
ethyl Bromopyruvate

: 220717-71-5
2-((S)-1-{[2-((S)-1-Benzyloxycarbonylamino-2-methyl-propyl)-oxazole-4-carbonyl]-amino}-2-methyl-propyl)-thiazole-4-carboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) KHCO₃, 2.) trifluoroacetic anhydride, 2,6-lutidine / 1.) DME, rt, 45 min, 2.) 0 deg C, 30 min, 0 deg C to rt

2: AcCl / ethanol / 0 deg C to rt, overnight

3: 94 percent / HOBt, EDCI / dimethylformamide / -10 deg C, 20 min, rt, 21 h

4: AcCl / ethanol / 0 deg C to rt, overnight

5: 85 percent / K₂CO₃ / CH₂Cl₂; methanol / 12 h / Ambient temperature

With 2,6-dimethylpyridine; potassium carbonate; benzotriazol-1-ol; potassium hydrogencarbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; acetyl chloride; trifluoroacetic anhydride; In methanol; ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jo981664i

Reference yield:

: 96929-02-1
(S)-(2-methyl-1-thiocarbamoylpropyl)carbamic acid tert-butyl ester

: 220717-71-5
2-((S)-1-{[2-((S)-1-Benzyloxycarbonylamino-2-methyl-propyl)-oxazole-4-carbonyl]-amino}-2-methyl-propyl)-thiazole-4-carboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) KHCO₃, 2.) trifluoroacetic anhydride, 2,6-lutidine / 1.) DME, rt, 45 min, 2.) 0 deg C, 30 min, 0 deg C to rt

2: AcCl / ethanol / 0 deg C to rt, overnight

3: 94 percent / HOBt, EDCI / dimethylformamide / -10 deg C, 20 min, rt, 21 h

4: AcCl / ethanol / 0 deg C to rt, overnight

5: 85 percent / K₂CO₃ / CH₂Cl₂; methanol / 12 h / Ambient temperature

With 2,6-dimethylpyridine; potassium carbonate; benzotriazol-1-ol; potassium hydrogencarbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; acetyl chloride; trifluoroacetic anhydride; In methanol; ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jo981664i