2-((S)-1-{[2-((S)-1-Benzyloxycarbonylamino-2-methyl-propyl)-oxazole-4-carbonyl]-amino}-2-methyl-propyl)-thiazole-4-carboxylic acid

Base Information

Chemical Name:2-((S)-1-{[2-((S)-1-Benzyloxycarbonylamino-2-methyl-propyl)-oxazole-4-carbonyl]-amino}-2-methyl-propyl)-thiazole-4-carboxylic acid
CAS No.:220717-72-6
Molecular Formula:C₂₄H₂₈N₄O₆S
Molecular Weight:500.576
Hs Code.:

Synonyms:2-((S)-1-{[2-((S)-1-Benzyloxycarbonylamino-2-methyl-propyl)-oxazole-4-carbonyl]-amino}-2-methyl-propyl)-thiazole-4-carboxylic acid

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Chemical Property of 2-((S)-1-{[2-((S)-1-Benzyloxycarbonylamino-2-methyl-propyl)-oxazole-4-carbonyl]-amino}-2-methyl-propyl)-thiazole-4-carboxylic acid

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Technology Process of 2-((S)-1-{[2-((S)-1-Benzyloxycarbonylamino-2-methyl-propyl)-oxazole-4-carbonyl]-amino}-2-methyl-propyl)-thiazole-4-carboxylic acid

There total 9 articles about 2-((S)-1-{[2-((S)-1-Benzyloxycarbonylamino-2-methyl-propyl)-oxazole-4-carbonyl]-amino}-2-methyl-propyl)-thiazole-4-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 220717-71-5
2-((S)-1-{[2-((S)-1-Benzyloxycarbonylamino-2-methyl-propyl)-oxazole-4-carbonyl]-amino}-2-methyl-propyl)-thiazole-4-carboxylic acid ethyl ester

: 220717-72-6
2-((S)-1-{[2-((S)-1-Benzyloxycarbonylamino-2-methyl-propyl)-oxazole-4-carbonyl]-amino}-2-methyl-propyl)-thiazole-4-carboxylic acid

Guidance literature:: With lithium hydroxide; In methanol; water; for 2h; 0 deg C to rt;
DOI:10.1021/jo981664i

Reference yield:

: 96929-02-1
(S)-(2-methyl-1-thiocarbamoylpropyl)carbamic acid tert-butyl ester

: 220717-72-6
2-((S)-1-{[2-((S)-1-Benzyloxycarbonylamino-2-methyl-propyl)-oxazole-4-carbonyl]-amino}-2-methyl-propyl)-thiazole-4-carboxylic acid

Guidance literature:: Multi-step reaction with 6 steps

1: 1.) KHCO₃, 2.) trifluoroacetic anhydride, 2,6-lutidine / 1.) DME, rt, 45 min, 2.) 0 deg C, 30 min, 0 deg C to rt

2: AcCl / ethanol / 0 deg C to rt, overnight

3: 94 percent / HOBt, EDCI / dimethylformamide / -10 deg C, 20 min, rt, 21 h

4: AcCl / ethanol / 0 deg C to rt, overnight

5: 85 percent / K₂CO₃ / CH₂Cl₂; methanol / 12 h / Ambient temperature

6: 100 percent / LiOH / methanol; H₂O / 2 h / 0 deg C to rt

With 2,6-dimethylpyridine; lithium hydroxide; potassium carbonate; benzotriazol-1-ol; potassium hydrogencarbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; acetyl chloride; trifluoroacetic anhydride; In methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1021/jo981664i

Reference yield:

: 96929-07-6
2-<(S)-1--2-methylpropyl>-4-carbethoxythiazole

: 220717-72-6
2-((S)-1-{[2-((S)-1-Benzyloxycarbonylamino-2-methyl-propyl)-oxazole-4-carbonyl]-amino}-2-methyl-propyl)-thiazole-4-carboxylic acid

Guidance literature:: Multi-step reaction with 5 steps

1: AcCl / ethanol / 0 deg C to rt, overnight

2: 94 percent / HOBt, EDCI / dimethylformamide / -10 deg C, 20 min, rt, 21 h

3: AcCl / ethanol / 0 deg C to rt, overnight

4: 85 percent / K₂CO₃ / CH₂Cl₂; methanol / 12 h / Ambient temperature

5: 100 percent / LiOH / methanol; H₂O / 2 h / 0 deg C to rt

With lithium hydroxide; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; acetyl chloride; In methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1021/jo981664i