tert-butyl (3S,5S,8S)-8-(benzyloxymethyl)-(S)-6-hydroxy-3-((1-(3-methoxypropyl)-1H-indazol-6-yl)methyl)-2,9-dimethyldecan-5-ylcarbamate

Base Information

Chemical Name:tert-butyl (3S,5S,8S)-8-(benzyloxymethyl)-(S)-6-hydroxy-3-((1-(3-methoxypropyl)-1H-indazol-6-yl)methyl)-2,9-dimethyldecan-5-ylcarbamate
CAS No.:953820-45-6
Molecular Formula:C₃₇H₅₇N₃O₅
Molecular Weight:623.877
Hs Code.:

Synonyms:tert-butyl (3S,5S,8S)-8-(benzyloxymethyl)-(S)-6-hydroxy-3-((1-(3-methoxypropyl)-1H-indazol-6-yl)methyl)-2,9-dimethyldecan-5-ylcarbamate

Suppliers and Price of tert-butyl (3S,5S,8S)-8-(benzyloxymethyl)-(S)-6-hydroxy-3-((1-(3-methoxypropyl)-1H-indazol-6-yl)methyl)-2,9-dimethyldecan-5-ylcarbamate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of tert-butyl (3S,5S,8S)-8-(benzyloxymethyl)-(S)-6-hydroxy-3-((1-(3-methoxypropyl)-1H-indazol-6-yl)methyl)-2,9-dimethyldecan-5-ylcarbamate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of tert-butyl (3S,5S,8S)-8-(benzyloxymethyl)-(S)-6-hydroxy-3-((1-(3-methoxypropyl)-1H-indazol-6-yl)methyl)-2,9-dimethyldecan-5-ylcarbamate

There total 22 articles about tert-butyl (3S,5S,8S)-8-(benzyloxymethyl)-(S)-6-hydroxy-3-((1-(3-methoxypropyl)-1H-indazol-6-yl)methyl)-2,9-dimethyldecan-5-ylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 953820-30-9
tert-butyl (2S,4S)-4-((1-(3-methoxypropyl)-1H-indazol-6-yl)methyl)-5-methyl-1-oxohexan-2-ylcarbamate

: 172901-00-7
(2S)-(benzyloxymethyl)-3-methyl-butyl bromide

: tert-butyl (3S,5S,8S)-8-(benzyloxymethyl)-(R)-6-hydroxy-3-((1-(3-methoxypropyl)-1H-indazol-6-yl)methyl)-2,9-dimethyldecan-5-ylcarbamate

: 953820-45-6
tert-butyl (3S,5S,8S)-8-(benzyloxymethyl)-(S)-6-hydroxy-3-((1-(3-methoxypropyl)-1H-indazol-6-yl)methyl)-2,9-dimethyldecan-5-ylcarbamate

Guidance literature:: (2S)-(benzyloxymethyl)-3-methyl-butyl bromide; With magnesium; In tetrahydrofuran; for 0.5h; Heating / reflux;

tert-butyl (2S,4S)-4-((1-(3-methoxypropyl)-1H-indazol-6-yl)methyl)-5-methyl-1-oxohexan-2-ylcarbamate; In tetrahydrofuran; at -78 - 20 ℃;

With water; ammonium chloride; In tetrahydrofuran;

Reference yield:

: 7597-18-4
6-nitroindazole

: tert-butyl (3S,5S,8S)-8-(benzyloxymethyl)-(R)-6-hydroxy-3-((1-(3-methoxypropyl)-1H-indazol-6-yl)methyl)-2,9-dimethyldecan-5-ylcarbamate

: 953820-45-6
tert-butyl (3S,5S,8S)-8-(benzyloxymethyl)-(S)-6-hydroxy-3-((1-(3-methoxypropyl)-1H-indazol-6-yl)methyl)-2,9-dimethyldecan-5-ylcarbamate

Guidance literature:: Multi-step reaction with 16 steps

1.1: potassium carbonate / acetonitrile / 60 °C

2.1: hydrogen / Raney nickel / methanol / 2 h / 20 °C

3.1: hydrogenchloride; sodium nitrite / water / 2 h / 0 °C

3.2: 1 h / 80 °C

4.1: triethylamine / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / acetonitrile / 15 h / 65 °C / 2585.81 Torr

5.1: sodium tetrahydroborate / methanol / 12 h / 20 - 40 °C

6.1: N-Bromosuccinimide; triphenylphosphine / dichloromethane / 12 h / 0 - 20 °C

7.1: n-butyllithium; 1,1,1,3,3,3-hexamethyl-disilazane / tetrahydrofuran / 3 h / -78 °C

7.2: 20 h / -78 - 20 °C

8.1: lithium hydroxide; water; dihydrogen peroxide / tetrahydrofuran / 12 h / 0 - 20 °C

9.1: lithium aluminium tetrahydride / tetrahydrofuran / 24 h / -78 - 20 °C

9.2: 0 °C

10.1: N-Bromosuccinimide; triphenylphosphine / dichloromethane / 12 h / 0 - 20 °C

11.1: n-butyllithium / tetrahydrofuran; hexane / 2 h / -78 °C

11.2: 13 h / -78 - 20 °C

12.1: hydrogenchloride; water / acetonitrile / 5 h / 20 °C

12.2: 0 °C

13.1: triethylamine / dichloromethane / 20 h / 0 - 20 °C

14.1: sodium tetrahydroborate / ethanol / 12 h / 20 - 40 °C

15.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 1.75 h / -60 - -50 °C

16.1: magnesium / tetrahydrofuran / 0.5 h / Heating / reflux

16.2: -78 - 20 °C

With hydrogenchloride; lithium hydroxide; sodium tetrahydroborate; N-Bromosuccinimide; lithium aluminium tetrahydride; n-butyllithium; oxalyl dichloride; water; hydrogen; dihydrogen peroxide; potassium carbonate; magnesium; dimethyl sulfoxide; triethylamine; triphenylphosphine; 1,1,1,3,3,3-hexamethyl-disilazane; sodium nitrite; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; methanol; ethanol; hexane; dichloromethane; water; acetonitrile; 15.1: Swern Oxidation;

Reference yield:

: 953820-19-4
6-iodo-1-(3-methoxypropyl)-1H-indazole

: tert-butyl (3S,5S,8S)-8-(benzyloxymethyl)-(R)-6-hydroxy-3-((1-(3-methoxypropyl)-1H-indazol-6-yl)methyl)-2,9-dimethyldecan-5-ylcarbamate

: 953820-45-6
tert-butyl (3S,5S,8S)-8-(benzyloxymethyl)-(S)-6-hydroxy-3-((1-(3-methoxypropyl)-1H-indazol-6-yl)methyl)-2,9-dimethyldecan-5-ylcarbamate

Guidance literature:: Multi-step reaction with 13 steps

1.1: triethylamine / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / acetonitrile / 15 h / 65 °C / 2585.81 Torr

2.1: sodium tetrahydroborate / methanol / 12 h / 20 - 40 °C

3.1: N-Bromosuccinimide; triphenylphosphine / dichloromethane / 12 h / 0 - 20 °C

4.1: n-butyllithium; 1,1,1,3,3,3-hexamethyl-disilazane / tetrahydrofuran / 3 h / -78 °C

4.2: 20 h / -78 - 20 °C

5.1: lithium hydroxide; water; dihydrogen peroxide / tetrahydrofuran / 12 h / 0 - 20 °C

6.1: lithium aluminium tetrahydride / tetrahydrofuran / 24 h / -78 - 20 °C

6.2: 0 °C

7.1: N-Bromosuccinimide; triphenylphosphine / dichloromethane / 12 h / 0 - 20 °C

8.1: n-butyllithium / tetrahydrofuran; hexane / 2 h / -78 °C

8.2: 13 h / -78 - 20 °C

9.1: hydrogenchloride; water / acetonitrile / 5 h / 20 °C

9.2: 0 °C

10.1: triethylamine / dichloromethane / 20 h / 0 - 20 °C

11.1: sodium tetrahydroborate / ethanol / 12 h / 20 - 40 °C

12.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 1.75 h / -60 - -50 °C

13.1: magnesium / tetrahydrofuran / 0.5 h / Heating / reflux

13.2: -78 - 20 °C

With hydrogenchloride; lithium hydroxide; sodium tetrahydroborate; N-Bromosuccinimide; lithium aluminium tetrahydride; n-butyllithium; oxalyl dichloride; water; dihydrogen peroxide; magnesium; dimethyl sulfoxide; triethylamine; triphenylphosphine; 1,1,1,3,3,3-hexamethyl-disilazane; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; methanol; ethanol; hexane; dichloromethane; acetonitrile; 12.1: Swern Oxidation;