1-[4-(2-benzyloxy-4-fluoro-phenyl)-2,6-diisopropyl-5-vinyl-pyridin-3-yl]-ethanol

Base Information

Chemical Name:1-[4-(2-benzyloxy-4-fluoro-phenyl)-2,6-diisopropyl-5-vinyl-pyridin-3-yl]-ethanol
CAS No.:503559-83-9
Molecular Formula:C₂₈H₃₂FNO₂
Molecular Weight:433.566
Hs Code.:

Synonyms:1-[4-(2-benzyloxy-4-fluoro-phenyl)-2,6-diisopropyl-5-vinyl-pyridin-3-yl]-ethanol

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Chemical Property of 1-[4-(2-benzyloxy-4-fluoro-phenyl)-2,6-diisopropyl-5-vinyl-pyridin-3-yl]-ethanol

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Technology Process of 1-[4-(2-benzyloxy-4-fluoro-phenyl)-2,6-diisopropyl-5-vinyl-pyridin-3-yl]-ethanol

There total 10 articles about 1-[4-(2-benzyloxy-4-fluoro-phenyl)-2,6-diisopropyl-5-vinyl-pyridin-3-yl]-ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 1184-53-8
methylcopper

: 202858-60-4
4-(2-benzyloxy-4-fluoro-phenyl)-2,6-diisopropyl-5-vinyl-pyridine-3-carbaldehyde

: 503559-83-9
1-[4-(2-benzyloxy-4-fluoro-phenyl)-2,6-diisopropyl-5-vinyl-pyridin-3-yl]-ethanol

Guidance literature:: In diethyl ether; toluene; at 0 ℃; for 0.5h;
DOI:10.1016/S0960-894X(02)00736-9

Reference yield:

: 1830-54-2
3-oxopentanedioic acid dimethyl ester

: 503559-83-9
1-[4-(2-benzyloxy-4-fluoro-phenyl)-2,6-diisopropyl-5-vinyl-pyridin-3-yl]-ethanol

Guidance literature:: Multi-step reaction with 10 steps

1: 64 percent / pyridine / 1,2-dichloro-ethane / 0 °C

2: 92 percent / NH₃ / methanol / 0 °C

3: 95 percent / K₂CO₃ / acetone / Heating

4: 78 percent / tetrahydrofuran / Heating

5: Red-Al<*> / tetrahydrofuran / 20 °C

6: PCC / CH₂Cl₂ / 20 °C

7: tetrahydrofuran / 20 °C

8: LiAlH₄ / tetrahydrofuran / 20 °C

9: PCC / CH₂Cl₂ / 20 °C

10: 99 percent / toluene; diethyl ether / 0.5 h / 0 °C

With pyridine; lithium aluminium tetrahydride; ammonia; potassium carbonate; sodium bis(2-methoxyethoxy)aluminium dihydride; pyridinium chlorochromate; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; 1,2-dichloro-ethane; acetone; toluene; 7: Wittig reaction;
DOI:10.1016/S0960-894X(02)00736-9

Reference yield:

: 470717-48-7
dimethyl 2,6-diisopropyl-4-oxo-2H-pyran-3,5-dicarboxylate

: 503559-83-9
1-[4-(2-benzyloxy-4-fluoro-phenyl)-2,6-diisopropyl-5-vinyl-pyridin-3-yl]-ethanol

Guidance literature:: Multi-step reaction with 9 steps

1: 92 percent / NH₃ / methanol / 0 °C

2: 95 percent / K₂CO₃ / acetone / Heating

3: 78 percent / tetrahydrofuran / Heating

4: Red-Al<*> / tetrahydrofuran / 20 °C

5: PCC / CH₂Cl₂ / 20 °C

6: tetrahydrofuran / 20 °C

7: LiAlH₄ / tetrahydrofuran / 20 °C

8: PCC / CH₂Cl₂ / 20 °C

9: 99 percent / toluene; diethyl ether / 0.5 h / 0 °C

With lithium aluminium tetrahydride; ammonia; potassium carbonate; sodium bis(2-methoxyethoxy)aluminium dihydride; pyridinium chlorochromate; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; acetone; toluene; 6: Wittig reaction;
DOI:10.1016/S0960-894X(02)00736-9