3-Pyridinemethanol, 5-ethyl-4-(4-fluoro-2-hydroxyphenyl)-a-methyl-2,6-bis(1-methylethyl)-, (aR,4S)-rel- (9CI)

Base Information

Chemical Name:3-Pyridinemethanol, 5-ethyl-4-(4-fluoro-2-hydroxyphenyl)-a-methyl-2,6-bis(1-methylethyl)-, (aR,4S)-rel- (9CI)
CAS No.:202917-22-4
Molecular Formula:C₂₁H₂₈FNO₂
Molecular Weight:345.457
Hs Code.:
Mol file:202917-22-4.mol

Synonyms:3-Pyridinemethanol, 5-ethyl-4-(4-fluoro-2-hydroxyphenyl)-a-methyl-2,6-bis(1-methylethyl)-, (aR,4S)-rel- (9CI);3-Pyridinemethanol, 5-ethyl-4-(4-fluoro-2-hydroxyphenyl)-a-methyl-2,6-bis(1-methylethyl)-, (aR,4S)-rel-

Suppliers and Price of 3-Pyridinemethanol, 5-ethyl-4-(4-fluoro-2-hydroxyphenyl)-a-methyl-2,6-bis(1-methylethyl)-, (aR,4S)-rel- (9CI)

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
(ALPHAR,4S)-REL-5-ETHYL-4-(4-FLUORO-2-HYDROXYPHENYL)-ALPHA-METHYL-2,6-BIS-(1-METHYLETHYL)-3-PYRIDINEMETHANOL 95.00%
5MG
$ 504.30

Total 0 raw suppliers

Chemical Property of 3-Pyridinemethanol, 5-ethyl-4-(4-fluoro-2-hydroxyphenyl)-a-methyl-2,6-bis(1-methylethyl)-, (aR,4S)-rel- (9CI)

Chemical Property:

PSA：52.49000
LogP:5.15790

Purity/Quality:: (ALPHAR,4S)-REL-5-ETHYL-4-(4-FLUORO-2-HYDROXYPHENYL)-ALPHA-METHYL-2,6-BIS-(1-METHYLETHYL)-3-PYRIDINEMETHANOL 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 3-Pyridinemethanol, 5-ethyl-4-(4-fluoro-2-hydroxyphenyl)-a-methyl-2,6-bis(1-methylethyl)-, (aR,4S)-rel- (9CI)

There total 11 articles about 3-Pyridinemethanol, 5-ethyl-4-(4-fluoro-2-hydroxyphenyl)-a-methyl-2,6-bis(1-methylethyl)-, (aR,4S)-rel- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 503559-83-9
1-[4-(2-benzyloxy-4-fluoro-phenyl)-2,6-diisopropyl-5-vinyl-pyridin-3-yl]-ethanol

: 202917-22-4,334992-03-9,503610-10-4
2-[3-ethyl-5-(1-hydroxy-ethyl)-2,6-diisopropyl-pyridin-4-yl]-5-fluoro-phenol

Guidance literature:: With hydrogen; palladium on activated charcoal; In ethanol;
DOI:10.1016/S0960-894X(02)00736-9

Reference yield:

: 1830-54-2
3-oxopentanedioic acid dimethyl ester

: 202917-22-4,334992-03-9,503610-10-4
2-[3-ethyl-5-(1-hydroxy-ethyl)-2,6-diisopropyl-pyridin-4-yl]-5-fluoro-phenol

Guidance literature:: Multi-step reaction with 11 steps

1: 64 percent / pyridine / 1,2-dichloro-ethane / 0 °C

2: 92 percent / NH₃ / methanol / 0 °C

3: 95 percent / K₂CO₃ / acetone / Heating

4: 78 percent / tetrahydrofuran / Heating

5: Red-Al<*> / tetrahydrofuran / 20 °C

6: PCC / CH₂Cl₂ / 20 °C

7: tetrahydrofuran / 20 °C

8: LiAlH₄ / tetrahydrofuran / 20 °C

9: PCC / CH₂Cl₂ / 20 °C

10: 99 percent / toluene; diethyl ether / 0.5 h / 0 °C

11: H₂ / Pd/C / ethanol

With pyridine; lithium aluminium tetrahydride; ammonia; hydrogen; potassium carbonate; sodium bis(2-methoxyethoxy)aluminium dihydride; pyridinium chlorochromate; palladium on activated charcoal; In tetrahydrofuran; methanol; diethyl ether; ethanol; dichloromethane; 1,2-dichloro-ethane; acetone; toluene; 7: Wittig reaction;
DOI:10.1016/S0960-894X(02)00736-9

Reference yield:

: 470717-48-7
dimethyl 2,6-diisopropyl-4-oxo-2H-pyran-3,5-dicarboxylate

: 202917-22-4,334992-03-9,503610-10-4
2-[3-ethyl-5-(1-hydroxy-ethyl)-2,6-diisopropyl-pyridin-4-yl]-5-fluoro-phenol

Guidance literature:: Multi-step reaction with 10 steps

1: 92 percent / NH₃ / methanol / 0 °C

2: 95 percent / K₂CO₃ / acetone / Heating

3: 78 percent / tetrahydrofuran / Heating

4: Red-Al<*> / tetrahydrofuran / 20 °C

5: PCC / CH₂Cl₂ / 20 °C

6: tetrahydrofuran / 20 °C

7: LiAlH₄ / tetrahydrofuran / 20 °C

8: PCC / CH₂Cl₂ / 20 °C

9: 99 percent / toluene; diethyl ether / 0.5 h / 0 °C

10: H₂ / Pd/C / ethanol

With lithium aluminium tetrahydride; ammonia; hydrogen; potassium carbonate; sodium bis(2-methoxyethoxy)aluminium dihydride; pyridinium chlorochromate; palladium on activated charcoal; In tetrahydrofuran; methanol; diethyl ether; ethanol; dichloromethane; acetone; toluene; 6: Wittig reaction;
DOI:10.1016/S0960-894X(02)00736-9