methyl (S)-1-(2-((2S,3S)-3-((1R,3S)-3-(benzyloxycarbonylamino)-2,2-dimethylcyclobutanecarboxamido)-2-hydroxy-4-phenylbutyl)-2-(4-(pyridin-2-yl)benzyl)hydrazinyl)-4-methyl-1-oxopentan-2-ylcarbamate

Base Information

Chemical Name:methyl (S)-1-(2-((2S,3S)-3-((1R,3S)-3-(benzyloxycarbonylamino)-2,2-dimethylcyclobutanecarboxamido)-2-hydroxy-4-phenylbutyl)-2-(4-(pyridin-2-yl)benzyl)hydrazinyl)-4-methyl-1-oxopentan-2-ylcarbamate
CAS No.:1313358-46-1
Molecular Formula:C₄₅H₅₆N₆O₇
Molecular Weight:792.976
Hs Code.:

methyl (S)-1-(2-((2S,3S)-3-((1R,3S)-3-(benzyloxycarbonylamino)-2,2-dimethylcyclobutanecarboxamido)-2-hydroxy-4-phenylbutyl)-2-(4-(pyridin-2-yl)benzyl)hydrazinyl)-4-methyl-1-oxopentan-2-ylcarbamate

Synonyms:methyl (S)-1-(2-((2S,3S)-3-((1R,3S)-3-(benzyloxycarbonylamino)-2,2-dimethylcyclobutanecarboxamido)-2-hydroxy-4-phenylbutyl)-2-(4-(pyridin-2-yl)benzyl)hydrazinyl)-4-methyl-1-oxopentan-2-ylcarbamate

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Chemical Property of methyl (S)-1-(2-((2S,3S)-3-((1R,3S)-3-(benzyloxycarbonylamino)-2,2-dimethylcyclobutanecarboxamido)-2-hydroxy-4-phenylbutyl)-2-(4-(pyridin-2-yl)benzyl)hydrazinyl)-4-methyl-1-oxopentan-2-ylcarbamate

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Technology Process of methyl (S)-1-(2-((2S,3S)-3-((1R,3S)-3-(benzyloxycarbonylamino)-2,2-dimethylcyclobutanecarboxamido)-2-hydroxy-4-phenylbutyl)-2-(4-(pyridin-2-yl)benzyl)hydrazinyl)-4-methyl-1-oxopentan-2-ylcarbamate

There total 12 articles about methyl (S)-1-(2-((2S,3S)-3-((1R,3S)-3-(benzyloxycarbonylamino)-2,2-dimethylcyclobutanecarboxamido)-2-hydroxy-4-phenylbutyl)-2-(4-(pyridin-2-yl)benzyl)hydrazinyl)-4-methyl-1-oxopentan-2-ylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(1R,3S)-3-(((benzyloxy)carbonyl)amino)-2,2-dimethylcyclobutan-1-carboxylic acid: 1017279-76-3
(1R,3S)-3-(((benzyloxy)carbonyl)amino)-2,2-dimethylcyclobutan-1-carboxylic acid

: 1313358-80-3
methyl (S)-1-(2-((2S,3S)-3-amino-2-hydroxy-4-phenylbutyl)-2-(4-(pyridin-2-yl)benzyl)hydrazinyl)-4-methyl-1-oxopentan-2-ylcarbamate

: 1313358-46-1
methyl (S)-1-(2-((2S,3S)-3-((1R,3S)-3-(benzyloxycarbonylamino)-2,2-dimethylcyclobutanecarboxamido)-2-hydroxy-4-phenylbutyl)-2-(4-(pyridin-2-yl)benzyl)hydrazinyl)-4-methyl-1-oxopentan-2-ylcarbamate

Guidance literature:: (1R,3S)-3-(((benzyloxy)carbonyl)amino)-2,2-dimethylcyclobutan-1-carboxylic acid; With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 0 ℃;

methyl (S)-1-(2-((2S,3S)-3-amino-2-hydroxy-4-phenylbutyl)-2-(4-(pyridin-2-yl)benzyl)hydrazinyl)-4-methyl-1-oxopentan-2-ylcarbamate; With 4-methyl-morpholine; In dichloromethane; N,N-dimethyl-formamide; at 20 ℃; for 24h;

Reference yield:

: 61-90-5,21675-61-6,25248-98-0,70-45-1
L-leucine

: 1313358-46-1
methyl (S)-1-(2-((2S,3S)-3-((1R,3S)-3-(benzyloxycarbonylamino)-2,2-dimethylcyclobutanecarboxamido)-2-hydroxy-4-phenylbutyl)-2-(4-(pyridin-2-yl)benzyl)hydrazinyl)-4-methyl-1-oxopentan-2-ylcarbamate

Guidance literature:: Multi-step reaction with 8 steps

1.1: sodium hydroxide / 1,4-dioxane; water / 18 h / 0 - 60 °C / pH 8 - 9

2.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; 4-methyl-morpholine / ethyl acetate / 0 °C

2.2: 18 h / 20 °C

3.1: hydrogenchloride; water / 1,4-dioxane / 12 h / 0 - 20 °C

4.1: isopropyl alcohol / 16 h / Reflux

5.1: hydrogen / palladium 10% on activated carbon / ethanol / 12 h / 20 °C

6.1: isopropyl alcohol / 16 h / Reflux

7.1: hydrogenchloride; water / tetrahydrofuran / 3 h / 0 - 50 °C

8.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 0 °C

8.2: 24 h / 20 °C

With 4-methyl-morpholine; hydrogenchloride; water; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium hydroxide; palladium 10% on activated carbon; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; water; ethyl acetate; isopropyl alcohol;

Reference yield:

: 80-57-9,1196-01-6
(-)-Verbenone

: 1313358-46-1
methyl (S)-1-(2-((2S,3S)-3-((1R,3S)-3-(benzyloxycarbonylamino)-2,2-dimethylcyclobutanecarboxamido)-2-hydroxy-4-phenylbutyl)-2-(4-(pyridin-2-yl)benzyl)hydrazinyl)-4-methyl-1-oxopentan-2-ylcarbamate

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium periodate; water / ruthenium(III) trichloride hydrate / tetrachloromethane; acetonitrile / 12 h / 0 - 20 °C

2.1: chloroformic acid ethyl ester; triethylamine / acetone / 3 h / 0 °C

2.2: 1.5 h / 0 - 20 °C

3.1: toluene / 4 h / 0 °C / Reflux

4.1: sodium hydroxide; bromine / water / 5 h / -5 °C

4.2: pH 2 - 3

5.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 0 °C

5.2: 24 h / 20 °C

With sodium periodate; water; bromine; chloroformic acid ethyl ester; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; sodium hydroxide; ruthenium(III) trichloride hydrate; In tetrachloromethane; dichloromethane; water; acetone; toluene; acetonitrile; 4.1: Lieben degradation;