methyl (S)-1-(2-((2S,3S)-3-amino-2-hydroxy-4-phenylbutyl)-2-(4-(pyridin-2-yl)benzyl)hydrazinyl)-4-methyl-1-oxopentan-2-ylcarbamate

Base Information

Chemical Name:methyl (S)-1-(2-((2S,3S)-3-amino-2-hydroxy-4-phenylbutyl)-2-(4-(pyridin-2-yl)benzyl)hydrazinyl)-4-methyl-1-oxopentan-2-ylcarbamate
CAS No.:1313358-80-3
Molecular Formula:C₃₀H₃₉N₅O₄
Molecular Weight:533.671
Hs Code.:

Synonyms:methyl (S)-1-(2-((2S,3S)-3-amino-2-hydroxy-4-phenylbutyl)-2-(4-(pyridin-2-yl)benzyl)hydrazinyl)-4-methyl-1-oxopentan-2-ylcarbamate

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Chemical Property of methyl (S)-1-(2-((2S,3S)-3-amino-2-hydroxy-4-phenylbutyl)-2-(4-(pyridin-2-yl)benzyl)hydrazinyl)-4-methyl-1-oxopentan-2-ylcarbamate

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Technology Process of methyl (S)-1-(2-((2S,3S)-3-amino-2-hydroxy-4-phenylbutyl)-2-(4-(pyridin-2-yl)benzyl)hydrazinyl)-4-methyl-1-oxopentan-2-ylcarbamate

There total 7 articles about methyl (S)-1-(2-((2S,3S)-3-amino-2-hydroxy-4-phenylbutyl)-2-(4-(pyridin-2-yl)benzyl)hydrazinyl)-4-methyl-1-oxopentan-2-ylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1313358-66-5
(S)-methyl 1-(2-((2S,3S)-3-(tert-butoxycarbonylamino)-2-hydroxy-4-phenylbutyl)-2-(4-(pyridin-2-yl)benzyl)hydrazinyl)-4-methyl-1-oxopentan-2-ylcarbamate

: 1313358-80-3
methyl (S)-1-(2-((2S,3S)-3-amino-2-hydroxy-4-phenylbutyl)-2-(4-(pyridin-2-yl)benzyl)hydrazinyl)-4-methyl-1-oxopentan-2-ylcarbamate

Guidance literature:: With hydrogenchloride; water; In tetrahydrofuran; at 0 - 50 ℃; for 3h;

Reference yield:

: 61-90-5,21675-61-6,25248-98-0,70-45-1
L-leucine

: 1313358-80-3
methyl (S)-1-(2-((2S,3S)-3-amino-2-hydroxy-4-phenylbutyl)-2-(4-(pyridin-2-yl)benzyl)hydrazinyl)-4-methyl-1-oxopentan-2-ylcarbamate

Guidance literature:: Multi-step reaction with 7 steps

1.1: sodium hydroxide / 1,4-dioxane; water / 18 h / 0 - 60 °C / pH 8 - 9

2.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; 4-methyl-morpholine / ethyl acetate / 0 °C

2.2: 18 h / 20 °C

3.1: hydrogenchloride; water / 1,4-dioxane / 12 h / 0 - 20 °C

4.1: isopropyl alcohol / 16 h / Reflux

5.1: hydrogen / palladium 10% on activated carbon / ethanol / 12 h / 20 °C

6.1: isopropyl alcohol / 16 h / Reflux

7.1: hydrogenchloride; water / tetrahydrofuran / 3 h / 0 - 50 °C

With 4-methyl-morpholine; hydrogenchloride; water; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium hydroxide; palladium 10% on activated carbon; In tetrahydrofuran; 1,4-dioxane; ethanol; water; ethyl acetate; isopropyl alcohol;

Reference yield:

: 74761-37-8
(S)-2-(methoxycarbonylamino)-4-methylpentanoic acid

: 1313358-80-3
methyl (S)-1-(2-((2S,3S)-3-amino-2-hydroxy-4-phenylbutyl)-2-(4-(pyridin-2-yl)benzyl)hydrazinyl)-4-methyl-1-oxopentan-2-ylcarbamate

Guidance literature:: Multi-step reaction with 6 steps

1.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; 4-methyl-morpholine / ethyl acetate / 0 °C

1.2: 18 h / 20 °C

2.1: hydrogenchloride; water / 1,4-dioxane / 12 h / 0 - 20 °C

3.1: isopropyl alcohol / 16 h / Reflux

4.1: hydrogen / palladium 10% on activated carbon / ethanol / 12 h / 20 °C

5.1: isopropyl alcohol / 16 h / Reflux

6.1: hydrogenchloride; water / tetrahydrofuran / 3 h / 0 - 50 °C

With 4-methyl-morpholine; hydrogenchloride; water; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; palladium 10% on activated carbon; In tetrahydrofuran; 1,4-dioxane; ethanol; ethyl acetate; isopropyl alcohol;