[(Z)-(S)-1-Benzyl-5-(ethyl-isopropyl-sulfamoyl)-pent-2-enyl]-carbamic acid benzyl ester

Base Information

• Chemical Name: [(Z)-(S)-1-Benzyl-5-(ethyl-isopropyl-sulfamoyl)-pent-2-enyl]-carbamic acid benzyl ester
• CAS No.: 200114-18-7
• Molecular Formula: C₂₅H₃₄N₂O₄S
• Molecular Weight: 458.622
• Mol file: 200114-18-7.mol

Synonyms:[(Z)-(S)-1-Benzyl-5-(ethyl-isopropyl-sulfamoyl)-pent-2-enyl]-carbamic acid benzyl ester

Chemical Property of [(Z)-(S)-1-Benzyl-5-(ethyl-isopropyl-sulfamoyl)-pent-2-enyl]-carbamic acid benzyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of [(Z)-(S)-1-Benzyl-5-(ethyl-isopropyl-sulfamoyl)-pent-2-enyl]-carbamic acid benzyl ester

There total 3 articles about [(Z)-(S)-1-Benzyl-5-(ethyl-isopropyl-sulfamoyl)-pent-2-enyl]-carbamic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

benzyl (1S)-(1-formyl-2-phenylethyl)carbamate (59830-60-3) + [3-(Ethyl-isopropyl-sulfamoyl)-propyl]-triphenyl-phosphonium; chloride → [(Z)-(S)-1-Benzyl-5-(ethyl-isopropyl-sulfamoyl)-pent-2-enyl]-carbamic acid benzyl ester (200114-18-7)

Guidance literature:

With potassium hexamethylsilazane; In tetrahydrofuran; at -40 - 20 ℃;

DOI:10.1016/S0960-894X(97)10054-3

Reference yield:

N-isopropylethylamine (19961-27-4) → [(Z)-(S)-1-Benzyl-5-(ethyl-isopropyl-sulfamoyl)-pent-2-enyl]-carbamic acid benzyl ester (200114-18-7)

Guidance literature:

Multi-step reaction with 3 steps

1: 93 percent / Et₃N / CH₂Cl₂

2: 95 percent / 110 °C

3: 86 percent / potassium bis(trimethylsilyl)amide / tetrahydrofuran / -40 - 20 °C

With potassium hexamethylsilazane; triethylamine; In tetrahydrofuran; dichloromethane;

DOI:10.1016/S0960-894X(97)10054-3

Reference yield:

3-Chloro-propane-1-sulfonic acid ethyl-isopropyl-amide (200114-16-5) → [(Z)-(S)-1-Benzyl-5-(ethyl-isopropyl-sulfamoyl)-pent-2-enyl]-carbamic acid benzyl ester (200114-18-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 95 percent / 110 °C

2: 86 percent / potassium bis(trimethylsilyl)amide / tetrahydrofuran / -40 - 20 °C

With potassium hexamethylsilazane; In tetrahydrofuran;

DOI:10.1016/S0960-894X(97)10054-3

upstream raw materials:

benzyl (1S)-(1-formyl-2-phenylethyl)carbamate

N-isopropylethylamine

3-Chloro-propane-1-sulfonic acid ethyl-isopropyl-amide

Downstream raw materials:

[(R)-1-((S)-1-{(2R,3S)-3-[2-(Ethyl-isopropyl-sulfamoyl)-ethyl]-oxiranyl}-2-phenyl-ethylcarbamoyl)-2-methanesulfonyl-2-methyl-propyl]-carbamic acid benzyl ester

((S)-1-{(2R,3S)-3-[2-(Ethyl-isopropyl-sulfamoyl)-ethyl]-oxiranyl}-2-phenyl-ethyl)-carbamic acid benzyl ester