59830-60-3

Basic information

• Product Name: CBZ-L-PHENYLALANINAL
• Synonyms: CBZ-L-PHENYLALANINAL;(S)-(-)-2-(Benzylcarbonylamino)-3-phenylpropanal;(S)-Benzyl (1-oxo-3-phenylpropan-2-yl)carbamate
• CAS NO: 59830-60-3
• Molecular Formula: C₁₇H₁₇NO₃
• Molecular Weight: 283.32178
• Mol File: 59830-60-3.mol
• Article Data: 94

Chemical Properties

• Boiling Point: 450.4 °C at 760 mmHg
• Flash Point: 226.2 °C
• Appearance: /
• Density: 1.168
• Storage Temp.: Inert atmosphere,Store in freezer, under -20°C
• CAS DataBase Reference: CBZ-L-PHENYLALANINAL(CAS DataBase Reference)
• NIST Chemistry Reference: CBZ-L-PHENYLALANINAL(59830-60-3)
• EPA Substance Registry System: CBZ-L-PHENYLALANINAL(59830-60-3)

Safety Data

• Hazardous Substances Data: 59830-60-3(Hazardous Substances Data)

Usage

General Description

CBZ-L-PHENYLALANINAL is a synthetic organic compound that belongs to the class of phenylalanine derivatives. It is commonly used as a starting material in the synthesis of various pharmaceuticals and fine chemicals. This chemical is known for its ability to selectively react with carboxylic acids, amines, and other functional groups, making it a versatile building block for chemical synthesis. CBZ-L-PHENYLALANINAL has also been studied for its potential pharmacological properties, particularly as an inhibitor of certain enzymes and receptors in the human body. Overall, this compound plays a crucial role in the development of new drugs and chemical compounds in the pharmaceutical industry.

Upstream product

• 3588-57-6 Z-DL-Phe-OH 
• 62750-39-4 1-<(Benzyl-carbobenzoxyamino)-acetyl>-imidazol 
• 114744-85-3 [(S)-1-(methoxy-methyl-carbamoyl)-2-phenyl-ethyl]-carbamic acid benzyl ester 
• 60718-38-9 (S)-2-benzyloxycarbonylamino-3-phenylthiopropanoic acid S-ethyl ester 
• 79-37-8 oxalyl dichloride 
• 6372-14-1 N-((benzyloxy)carbonyl)-L-phenylalaninol 
• 62750-39-4 ((S)-1-Benzyl-2-imidazol-1-yl-2-oxo-ethyl)-carbamic acid benzyl ester 
• 63-91-2 L-phenylalanine 
• 2577-90-4 methyl (2S)-2-amino-3-phenylpropanoate 
• 51987-73-6 (S)-2-tert-butoxycarbonylamino-3-phenyl-propionic acid methyl ester 
• 52641-32-4 N-benzyloxycarbonyl-L-phenylalanyl chloride 
• 3182-95-4 L-Phenylalaninol 
• 77-92-9 citric acid 
• 501-53-1 benzyl chloroformate 

Downstream Products

• 154659-14-0 (2S,3R,4R)-2--1,6-diphenylhexane-3,4-diol 
• 127041-76-3 ((S)-1-Benzyl-2-hydroxy-pent-4-enyl)-carbamic acid benzyl ester 
• 120452-52-0 ((S)-1-Benzyl-2-hydroxy-propyl)-carbamic acid benzyl ester 
• 114744-93-3 ((S)-1-Benzyl-2-hydroxy-butyl)-carbamic acid benzyl ester 
• 111871-62-6 (Z)-(S)-4-Benzyloxycarbonylamino-5-phenyl-pent-2-enoic acid methyl ester 
• 132618-89-4 methyl (E,4S)-4-(((benzyloxy)carbonyl)amino)-5-phenylpent-2-enoate 
• 150767-05-8 (S)-2-(phenylmethoxycarbonyl)amino-1-phenylbut-3-ene 
• 113283-75-3 [(S)-1-((4S,6S)-4,6-Dimethyl-[1,3]dioxan-2-yl)-2-phenyl-ethyl]-carbamic acid benzyl ester 
• 113283-78-6 [(S)-1-((4R,6R)-4,6-Dimethyl-[1,3]dioxan-2-yl)-2-phenyl-ethyl]-carbamic acid benzyl ester 
• 118219-45-7 (3S,4S)-4-Benzyloxycarbonylamino-3-hydroxy-5-phenyl-pentanoic acid (S)-2-hydroxy-1,2,2-triphenyl-ethyl ester 
• 130398-74-2 ((1S,2S)-1-Benzyl-2-{(S)-2-[1-diisopropylcarbamoyloxy-meth-(Z)-ylidene]-cyclopentyl}-2-hydroxy-ethyl)-carbamic acid benzyl ester 
• 130466-41-0 ((1S,2R)-1-Benzyl-2-{(R)-2-[1-diisopropylcarbamoyloxy-meth-(Z)-ylidene]-cyclopentyl}-2-hydroxy-ethyl)-carbamic acid benzyl ester 
• 86527-47-1 (S)-5-Benzyl-2-oxo-3-(tetrahydro-pyran-2-yloxy)-2,5-dihydro-pyrrole-1-carboxylic acid benzyl ester 
• 94014-70-7 5-benzyl-1-benzyloxycarbonyl-3-butyl-Δ³-pyrrolin-2-one 

Relevant articles and documents

The Chemical Development of LB71350

An efficient synthesis of the HIV-1 protease inhibitor LB71350 (1) is described. High diastereoselective epoxidation of the cis-allylic carbamate fragment of (5S)-[N-(benzyloxycarbonyl)-amino]-N-[2-methyl-(1R)-[(phenyl) carbonyl]-propyl]-6-phenylhex-(Z)-e

Regioselective Fluorination of α-Hydroxy-β-aminophosphonates by Using PyFluor

We report a simple protocol for the synthesis of α-fluoro-β-aminophosphonates by the regioselective fluorination of α-hydroxy-β-aminophosphonates under mild conditions. The fluorination reactions were mediated by the PyFluor reagent and occurred with the retention of configuration. The main products of this reaction were a series of α-fluoro-β-aminophosphonates, which can be used as precursors in the preparation of medicinally important compounds (e.g., dipeptide analogues).

Burgess Reagent Facilitated Alcohol Oxidations in DMSO

The Burgess reagent ([methoxycarbonylsulfamoyl]triethylammonium hydroxide) has historically found utility as a dehydrating agent. Herein we show that, in the presence of dimethyl sulfoxide, the Burgess reagent efficiently and rapidly facilitates the oxidation of a broad range of primary and secondary alcohols to their corresponding aldehydes and ketones in excellent yields and under mild conditions, and can be combined with other transformations (e.g., Wittig olefinations). A mechanism similar to those described for the Pfitzner-Moffatt and Swern oxidations is proposed.