Technology Process of N-(3-(3-(2-((2-methyl-1,2,3,4-tetrahydroisoquinolin-7-yl)amino)pyrimidin-4-yl)imidazo[1,2-a]pyridin-2-yl)phenyl)-1,3-thiazole-2-carboxamide
There total 14 articles about N-(3-(3-(2-((2-methyl-1,2,3,4-tetrahydroisoquinolin-7-yl)amino)pyrimidin-4-yl)imidazo[1,2-a]pyridin-2-yl)phenyl)-1,3-thiazole-2-carboxamide which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
1,3-thiazole-2-carboxylic acid; C27H25N7;
With
benzotriazol-1-ol;
In
N,N-dimethyl-formamide;
at 20 ℃;
for 16h;
With
ammonium hydroxide;
In
water; acetonitrile;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: sodium hydroxide / water; 1,2-dichloro-ethane / 0.17 h
1.2: 16 h / 90 °C
1.3: 1 h / 20 °C
2.1: hydrogen / palladium 10% on activated carbon / ethyl acetate / 16 h / 20 °C / 1551.49 Torr
3.1: hydrogenchloride / isopropyl alcohol; 1,4-dioxane / 0.92 h / 140 °C / Microwave irradiation
4.1: water; ammonium chloride; iron / ethanol / 1.5 h / 90 °C
5.1: benzotriazol-1-ol / N,N-dimethyl-formamide / 16 h / 20 °C
With
hydrogenchloride; water; hydrogen; iron; ammonium chloride; benzotriazol-1-ol; sodium hydroxide;
palladium 10% on activated carbon;
In
1,4-dioxane; ethanol; water; ethyl acetate; 1,2-dichloro-ethane; N,N-dimethyl-formamide; isopropyl alcohol;
- Guidance literature:
-
Multi-step reaction with 10 steps
1.1: sodium hydrogencarbonate / ethanol / 4 h / 20 °C
2.1: N-iodo-succinimide / N,N-dimethyl-formamide / 4 h / 20 °C
3.1: bis-triphenylphosphine-palladium(II) chloride / toluene / 27 h / 110 °C
3.2: 16 h / 20 °C
4.1: 1-methyl-pyrrolidin-2-one / 1.5 h / 90 °C
5.1: potassium carbonate / 1-methyl-pyrrolidin-2-one / 65 h / 97 °C
6.1: water; sodium nitrite; acetic acid / 0.75 h / 60 °C
6.2: 0 °C / pH 7
7.1: trichlorophosphate / 5 h / 80 °C
7.2: 20 °C / pH 11
8.1: hydrogenchloride / isopropyl alcohol; 1,4-dioxane / 0.92 h / 140 °C / Microwave irradiation
9.1: water; ammonium chloride; iron / ethanol / 1.5 h / 90 °C
10.1: benzotriazol-1-ol / N,N-dimethyl-formamide / 16 h / 20 °C
With
hydrogenchloride; N-iodo-succinimide; water; iron; sodium hydrogencarbonate; potassium carbonate; ammonium chloride; benzotriazol-1-ol; acetic acid; sodium nitrite; trichlorophosphate;
bis-triphenylphosphine-palladium(II) chloride;
In
1,4-dioxane; 1-methyl-pyrrolidin-2-one; ethanol; N,N-dimethyl-formamide; isopropyl alcohol; toluene;