benzyl N-(1S)-2-[(2S)-2-(1H-1,2,3-benzotriazol-1-ylcarbonyl)tetrahydro-1H-pyrrol-1-yl]-1-methyl-2-oxoethylcarbamate

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Chemical Name:benzyl N-(1S)-2-[(2S)-2-(1H-1,2,3-benzotriazol-1-ylcarbonyl)tetrahydro-1H-pyrrol-1-yl]-1-methyl-2-oxoethylcarbamate
CAS No.:1173817-68-9
Molecular Formula:C₂₂H₂₃N₅O₄
Molecular Weight:421.456
Hs Code.:

Synonyms:benzyl N-(1S)-2-[(2S)-2-(1H-1,2,3-benzotriazol-1-ylcarbonyl)tetrahydro-1H-pyrrol-1-yl]-1-methyl-2-oxoethylcarbamate

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Chemical Property of benzyl N-(1S)-2-[(2S)-2-(1H-1,2,3-benzotriazol-1-ylcarbonyl)tetrahydro-1H-pyrrol-1-yl]-1-methyl-2-oxoethylcarbamate

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Technology Process of benzyl N-(1S)-2-[(2S)-2-(1H-1,2,3-benzotriazol-1-ylcarbonyl)tetrahydro-1H-pyrrol-1-yl]-1-methyl-2-oxoethylcarbamate

There total 3 articles about benzyl N-(1S)-2-[(2S)-2-(1H-1,2,3-benzotriazol-1-ylcarbonyl)tetrahydro-1H-pyrrol-1-yl]-1-methyl-2-oxoethylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 95-14-7,27556-51-0
1,2,3-Benzotriazole

: 21027-01-0
N-benzyloxycarbonyl-L-alanyl-L-proline

: 1173817-68-9
benzyl N-(1S)-2-[(2S)-2-(1H-1,2,3-benzotriazol-1-ylcarbonyl)tetrahydro-1H-pyrrol-1-yl]-1-methyl-2-oxoethylcarbamate

Guidance literature:: With thionyl chloride; In dichloromethane; at -10 - 20 ℃;
DOI:10.1002/chem.201103143

Reference yield:

: 1142-20-7
N-Cbz-Ala

: 1173817-68-9
benzyl N-(1S)-2-[(2S)-2-(1H-1,2,3-benzotriazol-1-ylcarbonyl)tetrahydro-1H-pyrrol-1-yl]-1-methyl-2-oxoethylcarbamate

Guidance literature:: Multi-step reaction with 3 steps

1.1: thionyl chloride / tetrahydrofuran / 0.33 h / 20 °C

1.2: 2 h / 20 °C

2.1: triethylamine / water; acetonitrile / 0.08 h / 50 °C / Microwave irradiation

3.1: thionyl chloride / dichloromethane / -10 - 20 °C

With thionyl chloride; triethylamine; In tetrahydrofuran; dichloromethane; water; acetonitrile;
DOI:10.1002/chem.201103143

Reference yield:

: 820239-42-7
benzyl N-[(1S)-2-(1H-1,2,3-benzotriazol-1-yl)-1-methyl-2-oxoethyl]carbamate

: 1173817-68-9
benzyl N-(1S)-2-[(2S)-2-(1H-1,2,3-benzotriazol-1-ylcarbonyl)tetrahydro-1H-pyrrol-1-yl]-1-methyl-2-oxoethylcarbamate

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / water; acetonitrile / 0.08 h / 50 °C / Microwave irradiation

2: thionyl chloride / dichloromethane / -10 - 20 °C

With thionyl chloride; triethylamine; In dichloromethane; water; acetonitrile;
DOI:10.1002/chem.201103143