4-[1-hydroxy-2-methyl-1-(1-trityl-1H-imidazol-4-yl)propyl]phenylboronic acid

Base Information

Chemical Name:4-[1-hydroxy-2-methyl-1-(1-trityl-1H-imidazol-4-yl)propyl]phenylboronic acid
CAS No.:337536-20-6
Molecular Formula:C₃₂H₃₁BN₂O₃
Molecular Weight:502.421
Hs Code.:

Synonyms:4-[1-hydroxy-2-methyl-1-(1-trityl-1H-imidazol-4-yl)propyl]phenylboronic acid

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Chemical Property of 4-[1-hydroxy-2-methyl-1-(1-trityl-1H-imidazol-4-yl)propyl]phenylboronic acid

Chemical Property:

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Technology Process of 4-[1-hydroxy-2-methyl-1-(1-trityl-1H-imidazol-4-yl)propyl]phenylboronic acid

There total 4 articles about 4-[1-hydroxy-2-methyl-1-(1-trityl-1H-imidazol-4-yl)propyl]phenylboronic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 337535-23-6
1-(4-bromophenyl)-2-methyl-1-(1-trityl-1H-imidazol-4-yl)propan-1-ol

: 337536-20-6
4-[1-hydroxy-2-methyl-1-(1-trityl-1H-imidazol-4-yl)propyl]phenylboronic acid

Guidance literature:: 1-(4-bromophenyl)-2-methyl-1-(1-trityl-1H-imidazol-4-yl)propan-1-ol; With n-butyllithium; In tetrahydrofuran; diethyl ether; at -78 ℃; for 0.25h;

With Trimethyl borate; In tetrahydrofuran; diethyl ether; at -78 - 20 ℃;

With hydrogenchloride; water; In tetrahydrofuran; diethyl ether; at 20 ℃;
DOI:10.1016/j.bmc.2011.02.009

Reference yield:

: 121-43-7,63156-11-6
Trimethyl borate

: 106-37-6
1.4-dibromobenzene

: ammonium chloride

: 2-methyl-1-(1-trityl-1H-imidazol-4-yl)-1-propanone

: 337536-20-6
4-[1-hydroxy-2-methyl-1-(1-trityl-1H-imidazol-4-yl)propyl]phenylboronic acid

Guidance literature:: With n-butyllithium; In tetrahydrofuran; hexane;

Reference yield:

: 106-37-6
1.4-dibromobenzene

: 337536-20-6
4-[1-hydroxy-2-methyl-1-(1-trityl-1H-imidazol-4-yl)propyl]phenylboronic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: n-butyllithium / diethyl ether / 0.5 h / -78 °C

1.2: 0.5 h / -78 - -50 °C

2.1: n-butyllithium / tetrahydrofuran; diethyl ether / 0.25 h / -78 °C

2.2: -78 - 20 °C

2.3: 20 °C

With n-butyllithium; In tetrahydrofuran; diethyl ether;
DOI:10.1016/j.bmc.2011.02.009