4-{[3-(5-Amino-1H-pyrazol-4-yl)-3'-cyanobiphenyl-4-yl]oxy}-5-chloro-2-fluoro-N-(1,3,4-thiadiazol-2-yl)benzenesulfonamide

Base Information

Chemical Name:4-{[3-(5-Amino-1H-pyrazol-4-yl)-3'-cyanobiphenyl-4-yl]oxy}-5-chloro-2-fluoro-N-(1,3,4-thiadiazol-2-yl)benzenesulfonamide
CAS No.:1354786-44-9
Molecular Formula:C₂₄H₁₅ClFN₇O₃S₂
Molecular Weight:568.012
Hs Code.:

Synonyms:4-{[3-(5-Amino-1H-pyrazol-4-yl)-3'-cyanobiphenyl-4-yl]oxy}-5-chloro-2-fluoro-N-(1,3,4-thiadiazol-2-yl)benzenesulfonamide

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Chemical Property of 4-{[3-(5-Amino-1H-pyrazol-4-yl)-3'-cyanobiphenyl-4-yl]oxy}-5-chloro-2-fluoro-N-(1,3,4-thiadiazol-2-yl)benzenesulfonamide

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Technology Process of 4-{[3-(5-Amino-1H-pyrazol-4-yl)-3'-cyanobiphenyl-4-yl]oxy}-5-chloro-2-fluoro-N-(1,3,4-thiadiazol-2-yl)benzenesulfonamide

There total 6 articles about 4-{[3-(5-Amino-1H-pyrazol-4-yl)-3'-cyanobiphenyl-4-yl]oxy}-5-chloro-2-fluoro-N-(1,3,4-thiadiazol-2-yl)benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1354787-01-1
5-Chloro-4-(3'-cyano-3-(3-nitro-1H-pyrazol-4-yl)biphenyl-4-yloxy)-2-fluoro-N-(1,3,4-thiadiazol-2-yl)benzenesulfonamide

: 1354786-44-9
4-{[3-(5-Amino-1H-pyrazol-4-yl)-3'-cyanobiphenyl-4-yl]oxy}-5-chloro-2-fluoro-N-(1,3,4-thiadiazol-2-yl)benzenesulfonamide

Guidance literature:: With sodium dithionite; potassium carbonate; In water; acetonitrile; at 50 ℃; for 2h;

Reference yield:

: 150255-96-2
(3‐cyanophenyl)boronic acid

: 1354786-44-9
4-{[3-(5-Amino-1H-pyrazol-4-yl)-3'-cyanobiphenyl-4-yl]oxy}-5-chloro-2-fluoro-N-(1,3,4-thiadiazol-2-yl)benzenesulfonamide

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate; tetra(n-butyl)ammonium hydroxide / tri tert-butylphosphoniumtetrafluoroborate; bis({5-chloro-2-[(4-chlorophenyl)(hydroxyimino)methyl]phenyl})cyclodipalladachl-orane-1,3,4-tris(ylium)-2-uide / N,N-dimethyl-formamide; methanol / 1 h / 130 °C / Microwave irradiation; Sealed tube

2: potassium carbonate / dimethyl sulfoxide / 1 h / 20 °C

3: hydrogenchloride / 1,4-dioxane / 18 h / 20 °C

4: potassium carbonate; sodium dithionite / acetonitrile; water / 2 h / 50 °C

With hydrogenchloride; sodium dithionite; tetra(n-butyl)ammonium hydroxide; potassium carbonate; bis({5-chloro-2-[(4-chlorophenyl)(hydroxyimino)methyl]phenyl})cyclodipalladachl-orane-1,3,4-tris(ylium)-2-uide; tri tert-butylphosphoniumtetrafluoroborate; In 1,4-dioxane; methanol; water; dimethyl sulfoxide; N,N-dimethyl-formamide; acetonitrile; 1: Suzuki Coupling;

Reference yield:

: 1235407-57-4
4-Chloro-2-(3-nitro-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazol-4-yl)phenol

: 1354786-44-9
4-{[3-(5-Amino-1H-pyrazol-4-yl)-3'-cyanobiphenyl-4-yl]oxy}-5-chloro-2-fluoro-N-(1,3,4-thiadiazol-2-yl)benzenesulfonamide

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate; tetra(n-butyl)ammonium hydroxide / tri tert-butylphosphoniumtetrafluoroborate; bis({5-chloro-2-[(4-chlorophenyl)(hydroxyimino)methyl]phenyl})cyclodipalladachl-orane-1,3,4-tris(ylium)-2-uide / N,N-dimethyl-formamide; methanol / 1 h / 130 °C / Microwave irradiation; Sealed tube

2: potassium carbonate / dimethyl sulfoxide / 1 h / 20 °C

3: hydrogenchloride / 1,4-dioxane / 18 h / 20 °C

4: potassium carbonate; sodium dithionite / acetonitrile; water / 2 h / 50 °C

With hydrogenchloride; sodium dithionite; tetra(n-butyl)ammonium hydroxide; potassium carbonate; bis({5-chloro-2-[(4-chlorophenyl)(hydroxyimino)methyl]phenyl})cyclodipalladachl-orane-1,3,4-tris(ylium)-2-uide; tri tert-butylphosphoniumtetrafluoroborate; In 1,4-dioxane; methanol; water; dimethyl sulfoxide; N,N-dimethyl-formamide; acetonitrile; 1: Suzuki Coupling;