5-Chloro-4-(3'-cyano-3-(3-nitro-1H-pyrazol-4-yl)biphenyl-4-yloxy)-2-fluoro-N-(1,3,4-thiadiazol-2-yl)benzenesulfonamide

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Chemical Name:5-Chloro-4-(3'-cyano-3-(3-nitro-1H-pyrazol-4-yl)biphenyl-4-yloxy)-2-fluoro-N-(1,3,4-thiadiazol-2-yl)benzenesulfonamide
CAS No.:1354787-01-1
Molecular Formula:C₂₄H₁₃ClFN₇O₅S₂
Molecular Weight:597.995
Hs Code.:

Synonyms:5-Chloro-4-(3'-cyano-3-(3-nitro-1H-pyrazol-4-yl)biphenyl-4-yloxy)-2-fluoro-N-(1,3,4-thiadiazol-2-yl)benzenesulfonamide

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Chemical Property of 5-Chloro-4-(3'-cyano-3-(3-nitro-1H-pyrazol-4-yl)biphenyl-4-yloxy)-2-fluoro-N-(1,3,4-thiadiazol-2-yl)benzenesulfonamide

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Technology Process of 5-Chloro-4-(3'-cyano-3-(3-nitro-1H-pyrazol-4-yl)biphenyl-4-yloxy)-2-fluoro-N-(1,3,4-thiadiazol-2-yl)benzenesulfonamide

There total 5 articles about 5-Chloro-4-(3'-cyano-3-(3-nitro-1H-pyrazol-4-yl)biphenyl-4-yloxy)-2-fluoro-N-(1,3,4-thiadiazol-2-yl)benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: 1354787-02-2
5-Chloro-4-(3'-cyano-3-(3-nitro-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazol-4-yl)biphenyl-4-yloxy)-N-(2,4-dimethoxybenzyl)-2-fluoro-N-(1,3,4-thiadiazol-2-yl)benzenesulfonamide

: 1354787-01-1
5-Chloro-4-(3'-cyano-3-(3-nitro-1H-pyrazol-4-yl)biphenyl-4-yloxy)-2-fluoro-N-(1,3,4-thiadiazol-2-yl)benzenesulfonamide

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; at 20 ℃; for 18h;

Reference yield:

: 150255-96-2
(3‐cyanophenyl)boronic acid

: 1354787-01-1
5-Chloro-4-(3'-cyano-3-(3-nitro-1H-pyrazol-4-yl)biphenyl-4-yloxy)-2-fluoro-N-(1,3,4-thiadiazol-2-yl)benzenesulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate; tetra(n-butyl)ammonium hydroxide / tri tert-butylphosphoniumtetrafluoroborate; bis({5-chloro-2-[(4-chlorophenyl)(hydroxyimino)methyl]phenyl})cyclodipalladachl-orane-1,3,4-tris(ylium)-2-uide / N,N-dimethyl-formamide; methanol / 1 h / 130 °C / Microwave irradiation; Sealed tube

2: potassium carbonate / dimethyl sulfoxide / 1 h / 20 °C

3: hydrogenchloride / 1,4-dioxane / 18 h / 20 °C

With hydrogenchloride; tetra(n-butyl)ammonium hydroxide; potassium carbonate; bis({5-chloro-2-[(4-chlorophenyl)(hydroxyimino)methyl]phenyl})cyclodipalladachl-orane-1,3,4-tris(ylium)-2-uide; tri tert-butylphosphoniumtetrafluoroborate; In 1,4-dioxane; methanol; dimethyl sulfoxide; N,N-dimethyl-formamide; 1: Suzuki Coupling;

Reference yield:

: 1235407-57-4
4-Chloro-2-(3-nitro-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazol-4-yl)phenol

: 1354787-01-1
5-Chloro-4-(3'-cyano-3-(3-nitro-1H-pyrazol-4-yl)biphenyl-4-yloxy)-2-fluoro-N-(1,3,4-thiadiazol-2-yl)benzenesulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate; tetra(n-butyl)ammonium hydroxide / tri tert-butylphosphoniumtetrafluoroborate; bis({5-chloro-2-[(4-chlorophenyl)(hydroxyimino)methyl]phenyl})cyclodipalladachl-orane-1,3,4-tris(ylium)-2-uide / N,N-dimethyl-formamide; methanol / 1 h / 130 °C / Microwave irradiation; Sealed tube

2: potassium carbonate / dimethyl sulfoxide / 1 h / 20 °C

3: hydrogenchloride / 1,4-dioxane / 18 h / 20 °C

With hydrogenchloride; tetra(n-butyl)ammonium hydroxide; potassium carbonate; bis({5-chloro-2-[(4-chlorophenyl)(hydroxyimino)methyl]phenyl})cyclodipalladachl-orane-1,3,4-tris(ylium)-2-uide; tri tert-butylphosphoniumtetrafluoroborate; In 1,4-dioxane; methanol; dimethyl sulfoxide; N,N-dimethyl-formamide; 1: Suzuki Coupling;