<3(S,R),4(S,R),5(S,R)>-3-amino-5-(4-methoxyphenyl)-4-methyltetrahydrofuran-2-one hydrogen 4-toluenesulfonate

Base Information

Chemical Name:<3(S,R),4(S,R),5(S,R)>-3-amino-5-(4-methoxyphenyl)-4-methyltetrahydrofuran-2-one hydrogen 4-toluenesulfonate
CAS No.:131490-86-3
Molecular Formula:C₇H₈O₃S*C₁₂H₁₅NO₃
Molecular Weight:393.461
Hs Code.:

Synonyms:<3(S,R),4(S,R),5(S,R)>-3-amino-5-(4-methoxyphenyl)-4-methyltetrahydrofuran-2-one hydrogen 4-toluenesulfonate

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Chemical Property of <3(S,R),4(S,R),5(S,R)>-3-amino-5-(4-methoxyphenyl)-4-methyltetrahydrofuran-2-one hydrogen 4-toluenesulfonate

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Technology Process of <3(S,R),4(S,R),5(S,R)>-3-amino-5-(4-methoxyphenyl)-4-methyltetrahydrofuran-2-one hydrogen 4-toluenesulfonate

There total 4 articles about <3(S,R),4(S,R),5(S,R)>-3-amino-5-(4-methoxyphenyl)-4-methyltetrahydrofuran-2-one hydrogen 4-toluenesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 88155-33-3
<2(S,R),3(S,R),4(S,R)>-2-amino-4-hydroxy-4-(4-methoxyphenyl)-3-methylbutanoic acid

: 131490-86-3
<3(S,R),4(S,R),5(S,R)>-3-amino-5-(4-methoxyphenyl)-4-methyltetrahydrofuran-2-one hydrogen 4-toluenesulfonate

Guidance literature:: With toluene-4-sulfonic acid; In methanol; for 0.0833333h; Yield given;
DOI:10.1021/jo00005a042

Reference yield:

: 88072-83-7
<5(S,R),4(S,R)>-5-(4-methoxyphenyl)-4-methyl-N-tert-butylisoxazolinecarboxamide

: 131490-86-3
<3(S,R),4(S,R),5(S,R)>-3-amino-5-(4-methoxyphenyl)-4-methyltetrahydrofuran-2-one hydrogen 4-toluenesulfonate

Guidance literature:: Multi-step reaction with 3 steps

1: 47 percent / sodium bis(2-methoxyethoxy)aluminum hydride / tetrahydrofuran; toluene / 1.) -78 deg C, 1 h 2.) 4 deg C, 18 h

2: 65 percent / aq. NaOH / 48 h

3: 4-toluenesulfonic acid / methanol / 0.08 h

With sodium hydroxide; toluene-4-sulfonic acid; sodium bis(2-methoxyethoxy)aluminium dihydride; In tetrahydrofuran; methanol; toluene;
DOI:10.1021/jo00005a042

Reference yield:

: 131490-73-8
<2(S,R),3(S,R),4(S,R)>-2-amino-4-hydroxy-4-(4-methoxyphenyl)-3-methyl-N-tert-butylbutanamide

: 131490-86-3
<3(S,R),4(S,R),5(S,R)>-3-amino-5-(4-methoxyphenyl)-4-methyltetrahydrofuran-2-one hydrogen 4-toluenesulfonate

Guidance literature:: Multi-step reaction with 2 steps

1: 65 percent / aq. NaOH / 48 h

2: 4-toluenesulfonic acid / methanol / 0.08 h

With sodium hydroxide; toluene-4-sulfonic acid; In methanol;
DOI:10.1021/jo00005a042