2-methyl-2-[4-{[(4-methyl-2-[4-trifluoromethylphenyl]-thiazol-5-ylmethyl)-N-methyl-amino]methyl}phenoxy]propionic acid

Base Information

Chemical Name:2-methyl-2-[4-{[(4-methyl-2-[4-trifluoromethylphenyl]-thiazol-5-ylmethyl)-N-methyl-amino]methyl}phenoxy]propionic acid
CAS No.:1027251-82-6
Molecular Formula:C₂₄H₂₅F₃N₂O₃S
Molecular Weight:478.535
Hs Code.:

Synonyms:2-methyl-2-[4-{[(4-methyl-2-[4-trifluoromethylphenyl]-thiazol-5-ylmethyl)-N-methyl-amino]methyl}phenoxy]propionic acid

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Chemical Property of 2-methyl-2-[4-{[(4-methyl-2-[4-trifluoromethylphenyl]-thiazol-5-ylmethyl)-N-methyl-amino]methyl}phenoxy]propionic acid

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Technology Process of 2-methyl-2-[4-{[(4-methyl-2-[4-trifluoromethylphenyl]-thiazol-5-ylmethyl)-N-methyl-amino]methyl}phenoxy]propionic acid

There total 5 articles about 2-methyl-2-[4-{[(4-methyl-2-[4-trifluoromethylphenyl]-thiazol-5-ylmethyl)-N-methyl-amino]methyl}phenoxy]propionic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1347730-66-8
Example 39

: 1027251-82-6
2-methyl-2-[4-{[(4-methyl-2-[4-trifluoromethylphenyl]-thiazol-5-ylmethyl)-N-methyl-amino]methyl}phenoxy]propionic acid

Guidance literature:: Example 39; With sodium hydroxide; at 60 ℃; for 12h;

With hydrogenchloride;

Reference yield:

: 51336-35-7
α-(4-formylphenoxy)isobutyric acid ethyl ester

: 1027251-82-6
2-methyl-2-[4-{[(4-methyl-2-[4-trifluoromethylphenyl]-thiazol-5-ylmethyl)-N-methyl-amino]methyl}phenoxy]propionic acid

Guidance literature:: Multi-step reaction with 5 steps

1: sodium tetrahydroborate / methanol / 0.5 h / 25 °C

2: phosphorus tribromide / dichloromethane / 1 h / 25 °C

3: methylamine / tetrahydrofuran / 0.5 h / 50 °C

4: potassium carbonate; 5-(chloromethyl)-4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazole / 1 h

5: sodium hydroxide / 12 h / 60 °C

With sodium tetrahydroborate; sodium hydroxide; phosphorus tribromide; potassium carbonate; methylamine; 5-(chloromethyl)-4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazole; In tetrahydrofuran; methanol; dichloromethane;

Reference yield:

: 639784-43-3
ethyl 2-[4-(hydroxymethyl)phenoxy]-2-methylpropanoate

: 1027251-82-6
2-methyl-2-[4-{[(4-methyl-2-[4-trifluoromethylphenyl]-thiazol-5-ylmethyl)-N-methyl-amino]methyl}phenoxy]propionic acid

Guidance literature:: Multi-step reaction with 4 steps

1: phosphorus tribromide / dichloromethane / 1 h / 25 °C

2: methylamine / tetrahydrofuran / 0.5 h / 50 °C

3: potassium carbonate; 5-(chloromethyl)-4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazole / 1 h

4: sodium hydroxide / 12 h / 60 °C

With sodium hydroxide; phosphorus tribromide; potassium carbonate; methylamine; 5-(chloromethyl)-4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazole; In tetrahydrofuran; dichloromethane;