Technology Process of Example 39
There total 4 articles about Example 39 which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
potassium carbonate; 5-(chloromethyl)-4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazole;
for 1h;
- Guidance literature:
-
Multi-step reaction with 4 steps
1: sodium tetrahydroborate / methanol / 0.5 h / 25 °C
2: phosphorus tribromide / dichloromethane / 1 h / 25 °C
3: methylamine / tetrahydrofuran / 0.5 h / 50 °C
4: potassium carbonate; 5-(chloromethyl)-4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazole / 1 h
With
sodium tetrahydroborate; phosphorus tribromide; potassium carbonate; methylamine; 5-(chloromethyl)-4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazole;
In
tetrahydrofuran; methanol; dichloromethane;
- Guidance literature:
-
Multi-step reaction with 3 steps
1: phosphorus tribromide / dichloromethane / 1 h / 25 °C
2: methylamine / tetrahydrofuran / 0.5 h / 50 °C
3: potassium carbonate; 5-(chloromethyl)-4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazole / 1 h
With
phosphorus tribromide; potassium carbonate; methylamine; 5-(chloromethyl)-4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazole;
In
tetrahydrofuran; dichloromethane;