[(S)-5-{(S)-1-[(S)-1-Hydroxy-2-((S)-2-methyl-butylcarbamoyl)-ethyl]-3-methyl-butylcarbamoyl}-5-(3-naphthalen-1-yl-2-naphthalen-1-ylmethyl-propionylamino)-pentyl]-phosphoramidic acid diphenyl ester

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Chemical Name:[(S)-5-{(S)-1-[(S)-1-Hydroxy-2-((S)-2-methyl-butylcarbamoyl)-ethyl]-3-methyl-butylcarbamoyl}-5-(3-naphthalen-1-yl-2-naphthalen-1-ylmethyl-propionylamino)-pentyl]-phosphoramidic acid diphenyl ester
CAS No.:119809-25-5
Molecular Formula:C₅₅H₆₇N₄O₇P
Molecular Weight:927.133
Hs Code.:

[(S)-5-{(S)-1-[(S)-1-Hydroxy-2-((S)-2-methyl-butylcarbamoyl)-ethyl]-3-methyl-butylcarbamoyl}-5-(3-naphthalen-1-yl-2-naphthalen-1-ylmethyl-propionylamino)-pentyl]-phosphoramidic acid diphenyl ester

Synonyms:[(S)-5-{(S)-1-[(S)-1-Hydroxy-2-((S)-2-methyl-butylcarbamoyl)-ethyl]-3-methyl-butylcarbamoyl}-5-(3-naphthalen-1-yl-2-naphthalen-1-ylmethyl-propionylamino)-pentyl]-phosphoramidic acid diphenyl ester

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Chemical Property of [(S)-5-{(S)-1-[(S)-1-Hydroxy-2-((S)-2-methyl-butylcarbamoyl)-ethyl]-3-methyl-butylcarbamoyl}-5-(3-naphthalen-1-yl-2-naphthalen-1-ylmethyl-propionylamino)-pentyl]-phosphoramidic acid diphenyl ester

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Technology Process of [(S)-5-{(S)-1-[(S)-1-Hydroxy-2-((S)-2-methyl-butylcarbamoyl)-ethyl]-3-methyl-butylcarbamoyl}-5-(3-naphthalen-1-yl-2-naphthalen-1-ylmethyl-propionylamino)-pentyl]-phosphoramidic acid diphenyl ester

There total 7 articles about [(S)-5-{(S)-1-[(S)-1-Hydroxy-2-((S)-2-methyl-butylcarbamoyl)-ethyl]-3-methyl-butylcarbamoyl}-5-(3-naphthalen-1-yl-2-naphthalen-1-ylmethyl-propionylamino)-pentyl]-phosphoramidic acid diphenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 119808-15-0
(3S,4S)-4-[(S)-6-Amino-2-(3-naphthalen-1-yl-2-naphthalen-1-ylmethyl-propionylamino)-hexanoylamino]-3-hydroxy-6-methyl-heptanoic acid ((S)-2-methyl-butyl)-amide

: 2524-64-3
chlorophosphoric acid diphenyl ester

: 119809-25-5
[(S)-5-{(S)-1-[(S)-1-Hydroxy-2-((S)-2-methyl-butylcarbamoyl)-ethyl]-3-methyl-butylcarbamoyl}-5-(3-naphthalen-1-yl-2-naphthalen-1-ylmethyl-propionylamino)-pentyl]-phosphoramidic acid diphenyl ester

Guidance literature:: With triethylamine; In tetrahydrofuran; dichloromethane; at 0 ℃; for 3h;
DOI:10.1021/jm00108a004

Reference yield:

: 2389-45-9
Boc-Lys(Z)-OH

: 119809-25-5
[(S)-5-{(S)-1-[(S)-1-Hydroxy-2-((S)-2-methyl-butylcarbamoyl)-ethyl]-3-methyl-butylcarbamoyl}-5-(3-naphthalen-1-yl-2-naphthalen-1-ylmethyl-propionylamino)-pentyl]-phosphoramidic acid diphenyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 85.7 percent / dicyclohexylcarbodiimide (DCC), 1-hydroxybenzotriazole (HOBT), triethylamine (TEA) / dimethylformamide / 1.) 0 deg C, 1 h, 2.) RT, 16 h

2: 93.3 percent / trifluoroacetic acid (TFA) / CH₂Cl₂ / 6 h / Ambient temperature

3: 1.) 1-hydroxybenzotriazole (HOBT), dicyclohexylcarbodiimide (DCC) / 1.) DMF, 0 deg C, 10 min, 2.) a) 0 deg C, 1 h, b) RT, 24 h

4: 95.9 percent / H₂ / 20percent Pd/C / methanol / 8 h

5: 70 percent / triethylamine (TEA) / CH₂Cl₂; tetrahydrofuran / 3 h / 0 °C

With hydrogen; benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; trifluoroacetic acid; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm00108a004

Reference yield:

: 100002-50-4
{(S)-1-[(S)-1-Hydroxy-2-((S)-2-methyl-butylcarbamoyl)-ethyl]-3-methyl-butyl}-carbamic acid tert-butyl ester

: 119809-25-5
[(S)-5-{(S)-1-[(S)-1-Hydroxy-2-((S)-2-methyl-butylcarbamoyl)-ethyl]-3-methyl-butylcarbamoyl}-5-(3-naphthalen-1-yl-2-naphthalen-1-ylmethyl-propionylamino)-pentyl]-phosphoramidic acid diphenyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: HCl / CH₂Cl₂

2: 85.7 percent / dicyclohexylcarbodiimide (DCC), 1-hydroxybenzotriazole (HOBT), triethylamine (TEA) / dimethylformamide / 1.) 0 deg C, 1 h, 2.) RT, 16 h

3: 93.3 percent / trifluoroacetic acid (TFA) / CH₂Cl₂ / 6 h / Ambient temperature

4: 1.) 1-hydroxybenzotriazole (HOBT), dicyclohexylcarbodiimide (DCC) / 1.) DMF, 0 deg C, 10 min, 2.) a) 0 deg C, 1 h, b) RT, 24 h

5: 95.9 percent / H₂ / 20percent Pd/C / methanol / 8 h

6: 70 percent / triethylamine (TEA) / CH₂Cl₂; tetrahydrofuran / 3 h / 0 °C

With hydrogenchloride; hydrogen; benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; trifluoroacetic acid; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm00108a004