tert-butyl 1-(4-(2,2,2-trifluoro-1-(tosyloxyimino)ethyl)phenyl)ethylcarbamate

Base Information

Chemical Name:tert-butyl 1-(4-(2,2,2-trifluoro-1-(tosyloxyimino)ethyl)phenyl)ethylcarbamate
CAS No.:1241911-37-4
Molecular Formula:C₂₂H₂₅F₃N₂O₅S
Molecular Weight:486.512
Hs Code.:

Synonyms:tert-butyl 1-(4-(2,2,2-trifluoro-1-(tosyloxyimino)ethyl)phenyl)ethylcarbamate

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Chemical Property of tert-butyl 1-(4-(2,2,2-trifluoro-1-(tosyloxyimino)ethyl)phenyl)ethylcarbamate

Chemical Property:

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Technology Process of tert-butyl 1-(4-(2,2,2-trifluoro-1-(tosyloxyimino)ethyl)phenyl)ethylcarbamate

There total 5 articles about tert-butyl 1-(4-(2,2,2-trifluoro-1-(tosyloxyimino)ethyl)phenyl)ethylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 1241911-36-3
tert-butyl 1-(4-(2,2,2-trifluoro-1-(hydroxyimino)ethyl)phenyl)ethylcarbamate

: 98-59-9
p-toluenesulfonyl chloride

: 1241911-37-4
tert-butyl 1-(4-(2,2,2-trifluoro-1-(tosyloxyimino)ethyl)phenyl)ethylcarbamate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; dmap; In dichloromethane; at 0 - 20 ℃;

Reference yield:

: 24358-62-1
1-(4-bromophenyl)ethylamine

: 1241911-37-4
tert-butyl 1-(4-(2,2,2-trifluoro-1-(tosyloxyimino)ethyl)phenyl)ethylcarbamate

Guidance literature:: Multi-step reaction with 4 steps

1.1: triethylamine / dichloromethane / 0 - 20 °C

2.1: n-butyllithium / tetrahydrofuran; hexanes / 3.17 h / -78 °C / Inert atmosphere

2.2: 1.5 h / -78 °C

3.1: hydroxylamine hydrochloride; pyridine / ethanol / 16 h / 80 °C

4.1: dmap; N-ethyl-N,N-diisopropylamine / dichloromethane / 2 h / 0 - 20 °C

With pyridine; dmap; n-butyllithium; hydroxylamine hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; hexanes; ethanol; dichloromethane;

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 1241911-37-4
tert-butyl 1-(4-(2,2,2-trifluoro-1-(tosyloxyimino)ethyl)phenyl)ethylcarbamate

Guidance literature:: Multi-step reaction with 4 steps

1.1: triethylamine / dichloromethane / 0 - 20 °C

2.1: n-butyllithium / tetrahydrofuran; hexanes / 3.17 h / -78 °C / Inert atmosphere

2.2: 1.5 h / -78 °C

3.1: hydroxylamine hydrochloride; pyridine / ethanol / 16 h / 80 °C

4.1: dmap; N-ethyl-N,N-diisopropylamine / dichloromethane / 2 h / 0 - 20 °C

With pyridine; dmap; n-butyllithium; hydroxylamine hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; hexanes; ethanol; dichloromethane;