Technology Process of Boc-(2S,3R,4R)-4-chloro-3-hydroxyproline phenacyl ester
There total 4 articles about Boc-(2S,3R,4R)-4-chloro-3-hydroxyproline phenacyl ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
3-ethyl-2-chlorobenzoxazolium tetrafluoroborate; tetraethylammonium chloride; triethylamine;
In
dichloromethane;
for 48h;
Ambient temperature;
DOI:10.1246/bcsj.59.493
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 98 percent / triethylamine / ethyl acetate / 6 h / Ambient temperature
2: 22 percent / 2,6-di-t-butyl-p-cresol, m-chloroperbenzoic acid / CHCl3 / 3 h / Heating
3: 32 percent / tetraethylammonium chloride, 2-chloro-3-ethylbenzoxazolium tetrafluoroborate, triethylamine / CH2Cl2 / 48 h / Ambient temperature
With
2,6-di-tert-butyl-4-methyl-phenol; 3-ethyl-2-chlorobenzoxazolium tetrafluoroborate; tetraethylammonium chloride; triethylamine; 3-chloro-benzenecarboperoxoic acid;
In
dichloromethane; chloroform; ethyl acetate;
DOI:10.1246/bcsj.59.493
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 98 percent / triethylamine / ethyl acetate / 6 h / Ambient temperature
2: 22 percent / 2,6-di-t-butyl-p-cresol, m-chloroperbenzoic acid / CHCl3 / 3 h / Heating
3: 32 percent / tetraethylammonium chloride, 2-chloro-3-ethylbenzoxazolium tetrafluoroborate, triethylamine / CH2Cl2 / 48 h / Ambient temperature
With
2,6-di-tert-butyl-4-methyl-phenol; 3-ethyl-2-chlorobenzoxazolium tetrafluoroborate; tetraethylammonium chloride; triethylamine; 3-chloro-benzenecarboperoxoic acid;
In
dichloromethane; chloroform; ethyl acetate;
DOI:10.1246/bcsj.59.493
