dimethyl-4-(4-fluorophenyl)-1-methyl-2,6-dioxo-3,5-piperidinedicarboxylate

Base Information

Chemical Name:dimethyl-4-(4-fluorophenyl)-1-methyl-2,6-dioxo-3,5-piperidinedicarboxylate
CAS No.:511284-18-7
Molecular Formula:C₁₆H₁₆FNO₆
Molecular Weight:337.305
Hs Code.:

Synonyms:dimethyl-4-(4-fluorophenyl)-1-methyl-2,6-dioxo-3,5-piperidinedicarboxylate

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Chemical Property of dimethyl-4-(4-fluorophenyl)-1-methyl-2,6-dioxo-3,5-piperidinedicarboxylate

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Technology Process of dimethyl-4-(4-fluorophenyl)-1-methyl-2,6-dioxo-3,5-piperidinedicarboxylate

There total 6 articles about dimethyl-4-(4-fluorophenyl)-1-methyl-2,6-dioxo-3,5-piperidinedicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 616-38-6
carbonic acid dimethyl ester

: 511283-89-9
4-(4-fluorophenyl)-1-methylpiperidine-2,6-dione

: 511284-18-7
dimethyl-4-(4-fluorophenyl)-1-methyl-2,6-dioxo-3,5-piperidinedicarboxylate

Guidance literature:: carbonic acid dimethyl ester; 4-(4-fluorophenyl)-1-methylpiperidine-2,6-dione; In tetrahydrofuran; at 2 ℃;

With lithium hexamethyldisilazane; In tetrahydrofuran; for 0.666667h;

With acetic acid; In tetrahydrofuran; water; pH=>= 4; Product distribution / selectivity;

Reference yield:

: 17640-15-2
methyl cyanoformate

: 511283-89-9
4-(4-fluorophenyl)-1-methylpiperidine-2,6-dione

: (3R,4S)-4-(4-fluorophenyl)-1-methyl-2,6-dioxopiperidine-3-carboxylic acid methyl ester

: 188302-27-4
(3S,4R)-4-(4-fluorophenyl)-1-methyl-2,6-dioxopiperidine-3-carboxylic acid methyl ester

: 511284-18-7
dimethyl-4-(4-fluorophenyl)-1-methyl-2,6-dioxo-3,5-piperidinedicarboxylate

Guidance literature:: 4-(4-fluorophenyl)-1-methylpiperidine-2,6-dione; With (R,S,S,R)-PhCH(Me)N(Li)CH(Ph)CH(Ph)N(Li)CH(Me)Ph; In tetrahydrofuran; hexane; at -78 ℃;

methyl cyanoformate; In tetrahydrofuran; hexane; at -78 - -40 ℃; Title compound not separated from byproducts;
DOI:10.1055/s-2002-35588

Reference yield:

: 459-57-4
4-fluorobenzaldehyde

: 511284-18-7
dimethyl-4-(4-fluorophenyl)-1-methyl-2,6-dioxo-3,5-piperidinedicarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: acetic acid / piperidine / n-heptane / 3.5 h / Heating / reflux

2: potassium carbonate / acetic acid methyl ester / 18 h / Heating / reflux

With potassium carbonate; acetic acid; piperidine; In n-heptane; acetic acid methyl ester;