meso-(3R,4s,5S)-bis(2-hydroxyethyl) 4-(4-fluorophenyl)-1-methyl-2,6-dioxopiperidine-3,5-dicarboxylate

Base Information

Chemical Name:meso-(3R,4s,5S)-bis(2-hydroxyethyl) 4-(4-fluorophenyl)-1-methyl-2,6-dioxopiperidine-3,5-dicarboxylate
CAS No.:1099628-83-7
Molecular Formula:C₁₈H₂₀FNO₈
Molecular Weight:397.357
Hs Code.:

Synonyms:meso-(3R,4s,5S)-bis(2-hydroxyethyl) 4-(4-fluorophenyl)-1-methyl-2,6-dioxopiperidine-3,5-dicarboxylate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of meso-(3R,4s,5S)-bis(2-hydroxyethyl) 4-(4-fluorophenyl)-1-methyl-2,6-dioxopiperidine-3,5-dicarboxylate

Chemical Property:

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Technology Process of meso-(3R,4s,5S)-bis(2-hydroxyethyl) 4-(4-fluorophenyl)-1-methyl-2,6-dioxopiperidine-3,5-dicarboxylate

There total 7 articles about meso-(3R,4s,5S)-bis(2-hydroxyethyl) 4-(4-fluorophenyl)-1-methyl-2,6-dioxopiperidine-3,5-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 107-21-1
ethylene glycol

: 511284-18-7
dimethyl-4-(4-fluorophenyl)-1-methyl-2,6-dioxo-3,5-piperidinedicarboxylate

: 1099628-83-7
meso-(3R,4s,5S)-bis(2-hydroxyethyl) 4-(4-fluorophenyl)-1-methyl-2,6-dioxopiperidine-3,5-dicarboxylate

Guidance literature:: potassium cyanide;

Reference yield:

: 459-57-4
4-fluorobenzaldehyde

: 1099628-83-7
meso-(3R,4s,5S)-bis(2-hydroxyethyl) 4-(4-fluorophenyl)-1-methyl-2,6-dioxopiperidine-3,5-dicarboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: acetic acid / piperidine / n-heptane / 3.5 h / Heating / reflux

2: potassium carbonate / acetic acid methyl ester / 18 h / Heating / reflux

3: potassium cyanide

With potassium carbonate; acetic acid; piperidine; potassium cyanide; In n-heptane; acetic acid methyl ester;

Reference yield:

: 52927-40-9
dimethyl 2-(4-fluorobenzylidene)malonate

: 1099628-83-7
meso-(3R,4s,5S)-bis(2-hydroxyethyl) 4-(4-fluorophenyl)-1-methyl-2,6-dioxopiperidine-3,5-dicarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / acetic acid methyl ester / 18 h / Heating / reflux

2: potassium cyanide

With potassium carbonate; potassium cyanide; In acetic acid methyl ester;