(4aR,6R,8aS)-6-benzyloxymethyl-8a-(5-bromo-2-fluorophenyl)-4,4a,5,6,8,8a-hexahydro-7-oxa-3-thia-1-aza-naphthalen-2-ylamine

Base Information

Chemical Name:(4aR,6R,8aS)-6-benzyloxymethyl-8a-(5-bromo-2-fluorophenyl)-4,4a,5,6,8,8a-hexahydro-7-oxa-3-thia-1-aza-naphthalen-2-ylamine
CAS No.:1220329-30-5
Molecular Formula:C₂₁H₂₂BrFN₂O₂S
Molecular Weight:465.386
Hs Code.:

Synonyms:(4aR,6R,8aS)-6-benzyloxymethyl-8a-(5-bromo-2-fluorophenyl)-4,4a,5,6,8,8a-hexahydro-7-oxa-3-thia-1-aza-naphthalen-2-ylamine

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Chemical Property of (4aR,6R,8aS)-6-benzyloxymethyl-8a-(5-bromo-2-fluorophenyl)-4,4a,5,6,8,8a-hexahydro-7-oxa-3-thia-1-aza-naphthalen-2-ylamine

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Technology Process of (4aR,6R,8aS)-6-benzyloxymethyl-8a-(5-bromo-2-fluorophenyl)-4,4a,5,6,8,8a-hexahydro-7-oxa-3-thia-1-aza-naphthalen-2-ylamine

There total 1 articles about (4aR,6R,8aS)-6-benzyloxymethyl-8a-(5-bromo-2-fluorophenyl)-4,4a,5,6,8,8a-hexahydro-7-oxa-3-thia-1-aza-naphthalen-2-ylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1220329-28-1
[(2R,4R,5S)-5-amino-2-[(benzyloxy)methyl]-5-(5-bromo-2-fluorophenyl)tetrahydro-2H-pyran-4-yl]methanol

: 532-55-8
Benzoyl isothiocyanate

: 1220329-30-5
(4aR,6R,8aS)-6-benzyloxymethyl-8a-(5-bromo-2-fluorophenyl)-4,4a,5,6,8,8a-hexahydro-7-oxa-3-thia-1-aza-naphthalen-2-ylamine

Guidance literature:: [(2R,4R,5S)-5-amino-2-[(benzyloxy)methyl]-5-(5-bromo-2-fluorophenyl)tetrahydro-2H-pyran-4-yl]methanol; Benzoyl isothiocyanate; In dichloromethane; at 20 ℃; for 5h;

With hydrogenchloride; In methanol; for 6h; Reflux;

With 1,8-diazabicyclo[5.4.0]undec-7-ene; In methanol; for 3h; Reflux;

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 1220329-30-5
(4aR,6R,8aS)-6-benzyloxymethyl-8a-(5-bromo-2-fluorophenyl)-4,4a,5,6,8,8a-hexahydro-7-oxa-3-thia-1-aza-naphthalen-2-ylamine

: 1220329-32-7
tert-butyl [(4aR,6R,8aS)-8a-(5-bromo-2-fluorophenyl)-6-hydroxymethyl-4,4a,5,6,8,8a-hexahydro-7-oxa-3-thia-1-azanaphthalen-2-yl]carbamate

Guidance literature:: (4aR,6R,8aS)-6-benzyloxymethyl-8a-(5-bromo-2-fluorophenyl)-4,4a,5,6,8,8a-hexahydro-7-oxa-3-thia-1-aza-naphthalen-2-ylamine; With hydrogenchloride; for 2h; Reflux;

With sodium hydroxide; In water; at 20 ℃;

di-tert-butyl dicarbonate; With triethylamine; In tetrahydrofuran; at 20 ℃; for 6h;