[(2R,4R,5S)-5-amino-2-[(benzyloxy)methyl]-5-(5-bromo-2-fluorophenyl)tetrahydro-2H-pyran-4-yl]methanol

Base Information

Chemical Name:[(2R,4R,5S)-5-amino-2-[(benzyloxy)methyl]-5-(5-bromo-2-fluorophenyl)tetrahydro-2H-pyran-4-yl]methanol
CAS No.:1220329-28-1
Molecular Formula:C₂₀H₂₃BrFNO₃
Molecular Weight:424.31
Hs Code.:

Synonyms:[(2R,4R,5S)-5-amino-2-[(benzyloxy)methyl]-5-(5-bromo-2-fluorophenyl)tetrahydro-2H-pyran-4-yl]methanol

Suppliers and Price of [(2R,4R,5S)-5-amino-2-[(benzyloxy)methyl]-5-(5-bromo-2-fluorophenyl)tetrahydro-2H-pyran-4-yl]methanol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of [(2R,4R,5S)-5-amino-2-[(benzyloxy)methyl]-5-(5-bromo-2-fluorophenyl)tetrahydro-2H-pyran-4-yl]methanol

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of [(2R,4R,5S)-5-amino-2-[(benzyloxy)methyl]-5-(5-bromo-2-fluorophenyl)tetrahydro-2H-pyran-4-yl]methanol

There total 4 articles about [(2R,4R,5S)-5-amino-2-[(benzyloxy)methyl]-5-(5-bromo-2-fluorophenyl)tetrahydro-2H-pyran-4-yl]methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1220329-26-9
(3aR,5R,7aS)-5-(benzyloxymethyl)-7a-(5-bromo-2-fluorophenyl)-1,3,3a,4,5,7-hexahydropyrano[3,4-c]isoxazole

: 1220329-28-1
[(2R,4R,5S)-5-amino-2-[(benzyloxy)methyl]-5-(5-bromo-2-fluorophenyl)tetrahydro-2H-pyran-4-yl]methanol

Guidance literature:: (3aR,5R,7aS)-5-(benzyloxymethyl)-7a-(5-bromo-2-fluorophenyl)-1,3,3a,4,5,7-hexahydropyrano[3,4-c]isoxazole; With acetic acid; zinc; at 20 ℃;

With sodium hydroxide; In water; Cooling with ice;

Reference yield:

: 58931-16-1,88981-35-5,110339-28-1
(R)-1-benzyloxypent-4-en-2-ol

: 1220329-28-1
[(2R,4R,5S)-5-amino-2-[(benzyloxy)methyl]-5-(5-bromo-2-fluorophenyl)tetrahydro-2H-pyran-4-yl]methanol

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 30 °C

1.2: 19 h / 20 - 70 °C

2.1: formic acid; water / 2.5 h / 20 °C

2.2: 18 h / 20 °C

3.1: sodium hypochlorite / water; dichloromethane / 1.5 h / 0 - 15 °C

4.1: boron trifluoride diethyl etherate / toluene / 0.5 h / -78 °C

4.2: 1.5 h / -78 °C

5.1: molybdenum hexacarbonyl; water / acetonitrile / 0.5 h / Reflux

5.2: 3 h / Reflux

With sodium hypochlorite; formic acid; boron trifluoride diethyl etherate; water; sodium hydride; molybdenum hexacarbonyl; In tetrahydrofuran; dichloromethane; water; toluene; acetonitrile; mineral oil;

Reference yield:

: 1220328-95-9
2-{[(2R)-1-(benzyloxy)pent-4-en-2-yl]oxy}-N-hydroxyethanimine

: 1220329-28-1
[(2R,4R,5S)-5-amino-2-[(benzyloxy)methyl]-5-(5-bromo-2-fluorophenyl)tetrahydro-2H-pyran-4-yl]methanol

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hypochlorite / water; dichloromethane / 1.5 h / 0 - 15 °C

2.1: boron trifluoride diethyl etherate / toluene / 0.5 h / -78 °C

2.2: 1.5 h / -78 °C

3.1: molybdenum hexacarbonyl; water / acetonitrile / 0.5 h / Reflux

3.2: 3 h / Reflux

With sodium hypochlorite; boron trifluoride diethyl etherate; water; molybdenum hexacarbonyl; In dichloromethane; water; toluene; acetonitrile;