N-{4-[(2S,3R,4R,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-3-(tert-butyl-dimethyl-silanyloxy)-4-hydroxy-tetrahydro-furan-2-yl]-phenyl}-2,2,2-trifluoro-acetamide

Base Information

Chemical Name:N-{4-[(2S,3R,4R,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-3-(tert-butyl-dimethyl-silanyloxy)-4-hydroxy-tetrahydro-furan-2-yl]-phenyl}-2,2,2-trifluoro-acetamide
CAS No.:179762-60-8
Molecular Formula:C₄₀H₄₆F₃NO₇Si
Molecular Weight:737.888
Hs Code.:

N-{4-[(2S,3R,4R,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-3-(tert-butyl-dimethyl-silanyloxy)-4-hydroxy-tetrahydro-furan-2-yl]-phenyl}-2,2,2-trifluoro-acetamide

Synonyms:N-{4-[(2S,3R,4R,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-3-(tert-butyl-dimethyl-silanyloxy)-4-hydroxy-tetrahydro-furan-2-yl]-phenyl}-2,2,2-trifluoro-acetamide

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Chemical Property of N-{4-[(2S,3R,4R,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-3-(tert-butyl-dimethyl-silanyloxy)-4-hydroxy-tetrahydro-furan-2-yl]-phenyl}-2,2,2-trifluoro-acetamide

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Technology Process of N-{4-[(2S,3R,4R,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-3-(tert-butyl-dimethyl-silanyloxy)-4-hydroxy-tetrahydro-furan-2-yl]-phenyl}-2,2,2-trifluoro-acetamide

There total 15 articles about N-{4-[(2S,3R,4R,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-3-(tert-butyl-dimethyl-silanyloxy)-4-hydroxy-tetrahydro-furan-2-yl]-phenyl}-2,2,2-trifluoro-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 589-87-7
1,4-bromoiodobenzene

: 179762-60-8
N-{4-[(2S,3R,4R,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-3-(tert-butyl-dimethyl-silanyloxy)-4-hydroxy-tetrahydro-furan-2-yl]-phenyl}-2,2,2-trifluoro-acetamide

Guidance literature:: Multi-step reaction with 8 steps

1: 1.) BuLi / 1.) ether/hexane, RT, 40 min, 2.) ether/hexane/THF, 1 h, -78 deg C

2: Et₃SiH, BF₃Et₂O / acetonitrile / -40 °C

3: 63 percent / NH₃, CuI / 115 °C

4: pyridine

5: 1 M TBAF / tetrahydrofuran

6: 70percent aq. AcOH / 0.25 h / Heating

7: 70 percent / DMAP, Et₃N, pyridine

8: pyridine, AgNO₃ / tetrahydrofuran

With pyridine; triethylsilane; dmap; copper(l) iodide; n-butyllithium; boron trifluoride diethyl etherate; tetrabutyl ammonium fluoride; ammonia; silver nitrate; acetic acid; triethylamine; In tetrahydrofuran; acetonitrile;
DOI:10.1016/0040-4039(96)01576-6

Reference yield:

: 130222-84-3
5-(tert-butyldiphenylsilyl)-2,3-O-isopropylidene-D-ribono-1,4-lactone

: 179762-60-8
N-{4-[(2S,3R,4R,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-3-(tert-butyl-dimethyl-silanyloxy)-4-hydroxy-tetrahydro-furan-2-yl]-phenyl}-2,2,2-trifluoro-acetamide

Guidance literature:: Multi-step reaction with 5 steps

2: Et₃SiH-BF₃ / diethyl ether; acetonitrile / -40 °C

3: 1.) TBAF, 2.) aq. AcOH / 1.) THF, 2.) reflux

4: DMAO, Et₃N / pyridine

5: AgNO₃, pyridine / tetrahydrofuran

With pyridine; triethylsilane; boron trifluoride; tetrabutyl ammonium fluoride; silver nitrate; acetic acid; triethylamine; In tetrahydrofuran; pyridine; diethyl ether; acetonitrile;

Reference yield:

: 106-37-6
1.4-dibromobenzene

: 179762-60-8
N-{4-[(2S,3R,4R,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-3-(tert-butyl-dimethyl-silanyloxy)-4-hydroxy-tetrahydro-furan-2-yl]-phenyl}-2,2,2-trifluoro-acetamide

Guidance literature:: Multi-step reaction with 8 steps

1: 1.) BuLi / 1.) ether/hexane, RT, 40 min, 2.) ether/hexane/THF, 1 h, -78 deg C

2: Et₃SiH, BF₃Et₂O / acetonitrile / -40 °C

3: 63 percent / NH₃, CuI / 115 °C

4: pyridine

5: 1 M TBAF / tetrahydrofuran

6: 70percent aq. AcOH / 0.25 h / Heating

7: 70 percent / DMAP, Et₃N, pyridine

8: pyridine, AgNO₃ / tetrahydrofuran

With pyridine; triethylsilane; dmap; copper(l) iodide; n-butyllithium; boron trifluoride diethyl etherate; tetrabutyl ammonium fluoride; ammonia; silver nitrate; acetic acid; triethylamine; In tetrahydrofuran; acetonitrile;
DOI:10.1016/0040-4039(96)01576-6