4-[N',N''-bis(tert-butyloxycarbonyl)guanidino]phenyl N-(benzyloxycarbonyl)-α-(difluoromethyl)-D,L-phenylalaninate

Base Information

Chemical Name:4-[N',N''-bis(tert-butyloxycarbonyl)guanidino]phenyl N-(benzyloxycarbonyl)-α-(difluoromethyl)-D,L-phenylalaninate
CAS No.:515871-96-2
Molecular Formula:C₃₅H₄₀F₂N₄O₈
Molecular Weight:682.721
Hs Code.:

Synonyms:4-[N',N''-bis(tert-butyloxycarbonyl)guanidino]phenyl N-(benzyloxycarbonyl)-α-(difluoromethyl)-D,L-phenylalaninate

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Chemical Property of 4-[N',N''-bis(tert-butyloxycarbonyl)guanidino]phenyl N-(benzyloxycarbonyl)-α-(difluoromethyl)-D,L-phenylalaninate

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Technology Process of 4-[N',N''-bis(tert-butyloxycarbonyl)guanidino]phenyl N-(benzyloxycarbonyl)-α-(difluoromethyl)-D,L-phenylalaninate

There total 4 articles about 4-[N',N''-bis(tert-butyloxycarbonyl)guanidino]phenyl N-(benzyloxycarbonyl)-α-(difluoromethyl)-D,L-phenylalaninate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 226087-02-1
4-[N',N''-bis(tert-butyloxycarbonyl)guanidino]phenol

: 2-benzyl-2-benzyloxycarbonylamino-3,3-difluoro-propionic acid [1,2,3]triazolo[4,5-b]pyridin-3-yl ester

: 515871-96-2
4-[N',N''-bis(tert-butyloxycarbonyl)guanidino]phenyl N-(benzyloxycarbonyl)-α-(difluoromethyl)-D,L-phenylalaninate

Guidance literature:: With n-butyllithium; In tetrahydrofuran; hexane; at 20 ℃; for 2.58333h;
DOI:10.1021/jo020613p

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 515871-96-2
4-[N',N''-bis(tert-butyloxycarbonyl)guanidino]phenyl N-(benzyloxycarbonyl)-α-(difluoromethyl)-D,L-phenylalaninate

Guidance literature:: Multi-step reaction with 3 steps

1: dioxane / 24 h / 20 °C / pH 7.0

2: tetrahydrofuran / 20 °C

3: 83 percent / n-butyllithium / tetrahydrofuran; hexane / 2.58 h / 20 °C

With n-butyllithium; In tetrahydrofuran; 1,4-dioxane; hexane;
DOI:10.1021/jo020613p

Reference yield:

: 322474-21-5
N,N'-bis-Boc-S-methyl-isothiourea

: 515871-96-2
4-[N',N''-bis(tert-butyloxycarbonyl)guanidino]phenyl N-(benzyloxycarbonyl)-α-(difluoromethyl)-D,L-phenylalaninate

Guidance literature:: Multi-step reaction with 2 steps

1: tetrahydrofuran / 20 °C

2: 83 percent / n-butyllithium / tetrahydrofuran; hexane / 2.58 h / 20 °C

With n-butyllithium; In tetrahydrofuran; hexane;
DOI:10.1021/jo020613p