(3R,5R,6R,7R,9R,11R,12R,13S,14R)-6-((2S,3R,4S,6R)-4-Dimethylamino-3-hydroxy-6-methyl-tetrahydro-pyran-2-yloxy)-14-ethyl-12,13-dihydroxy-3,5,7,9,11,13-hexamethyl-7-((E)-3-phenyl-allyloxy)-oxacyclotetradecane-2,4,10-trione

Base Information

Chemical Name:(3R,5R,6R,7R,9R,11R,12R,13S,14R)-6-((2S,3R,4S,6R)-4-Dimethylamino-3-hydroxy-6-methyl-tetrahydro-pyran-2-yloxy)-14-ethyl-12,13-dihydroxy-3,5,7,9,11,13-hexamethyl-7-((E)-3-phenyl-allyloxy)-oxacyclotetradecane-2,4,10-trione
CAS No.:206997-54-8
Molecular Formula:C₃₈H₅₉NO₁₀
Molecular Weight:689.887
Hs Code.:

(3R,5R,6R,7R,9R,11R,12R,13S,14R)-6-((2S,3R,4S,6R)-4-Dimethylamino-3-hydroxy-6-methyl-tetrahydro-pyran-2-yloxy)-14-ethyl-12,13-dihydroxy-3,5,7,9,11,13-hexamethyl-7-((E)-3-phenyl-allyloxy)-oxacyclotetradecane-2,4,10-trione

Synonyms:(3R,5R,6R,7R,9R,11R,12R,13S,14R)-6-((2S,3R,4S,6R)-4-Dimethylamino-3-hydroxy-6-methyl-tetrahydro-pyran-2-yloxy)-14-ethyl-12,13-dihydroxy-3,5,7,9,11,13-hexamethyl-7-((E)-3-phenyl-allyloxy)-oxacyclotetradecane-2,4,10-trione

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Chemical Property of (3R,5R,6R,7R,9R,11R,12R,13S,14R)-6-((2S,3R,4S,6R)-4-Dimethylamino-3-hydroxy-6-methyl-tetrahydro-pyran-2-yloxy)-14-ethyl-12,13-dihydroxy-3,5,7,9,11,13-hexamethyl-7-((E)-3-phenyl-allyloxy)-oxacyclotetradecane-2,4,10-trione

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Technology Process of (3R,5R,6R,7R,9R,11R,12R,13S,14R)-6-((2S,3R,4S,6R)-4-Dimethylamino-3-hydroxy-6-methyl-tetrahydro-pyran-2-yloxy)-14-ethyl-12,13-dihydroxy-3,5,7,9,11,13-hexamethyl-7-((E)-3-phenyl-allyloxy)-oxacyclotetradecane-2,4,10-trione

There total 9 articles about (3R,5R,6R,7R,9R,11R,12R,13S,14R)-6-((2S,3R,4S,6R)-4-Dimethylamino-3-hydroxy-6-methyl-tetrahydro-pyran-2-yloxy)-14-ethyl-12,13-dihydroxy-3,5,7,9,11,13-hexamethyl-7-((E)-3-phenyl-allyloxy)-oxacyclotetradecane-2,4,10-trione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 381222-32-8
Benzoic acid (2S,3R,4S,6R)-4-dimethylamino-2-[(3R,5R,6R,7R,9R,11R,12R,13S,14R)-14-ethyl-12,13-dihydroxy-3,5,7,9,11,13-hexamethyl-2,4,10-trioxo-7-((E)-3-phenyl-allyloxy)-oxacyclotetradec-6-yloxy]-6-methyl-tetrahydro-pyran-3-yl ester

: 206997-54-8
(3R,5R,6R,7R,9R,11R,12R,13S,14R)-6-((2S,3R,4S,6R)-4-Dimethylamino-3-hydroxy-6-methyl-tetrahydro-pyran-2-yloxy)-14-ethyl-12,13-dihydroxy-3,5,7,9,11,13-hexamethyl-7-((E)-3-phenyl-allyloxy)-oxacyclotetradecane-2,4,10-trione

Guidance literature:: With methanol; for 6h; Heating;
DOI:10.1021/jm0102349

Reference yield:

: 591-50-4
iodobenzene

: 206997-54-8
(3R,5R,6R,7R,9R,11R,12R,13S,14R)-6-((2S,3R,4S,6R)-4-Dimethylamino-3-hydroxy-6-methyl-tetrahydro-pyran-2-yloxy)-14-ethyl-12,13-dihydroxy-3,5,7,9,11,13-hexamethyl-7-((E)-3-phenyl-allyloxy)-oxacyclotetradecane-2,4,10-trione

Guidance literature:: Multi-step reaction with 2 steps

1: 90 percent / Pd(OAc)2; Ph₃P; Et₃N / acetonitrile / 12.5 h / 60 - 80 °C

2: 70 percent / MeOH / 6 h / Heating

With methanol; palladium diacetate; triethylamine; triphenylphosphine; In acetonitrile; 1: Heck coupling;
DOI:10.1021/jm0102349

Reference yield:

: 205109-97-3
Benzoic acid (2S,3R,4S,6R)-2-((3R,5R,6R,7R,9R,11R,12R,13S,14R)-7-allyloxy-14-ethyl-12,13-dihydroxy-3,5,7,9,11,13-hexamethyl-2,4,10-trioxo-oxacyclotetradec-6-yloxy)-4-dimethylamino-6-methyl-tetrahydro-pyran-3-yl ester

: 206997-54-8
(3R,5R,6R,7R,9R,11R,12R,13S,14R)-6-((2S,3R,4S,6R)-4-Dimethylamino-3-hydroxy-6-methyl-tetrahydro-pyran-2-yloxy)-14-ethyl-12,13-dihydroxy-3,5,7,9,11,13-hexamethyl-7-((E)-3-phenyl-allyloxy)-oxacyclotetradecane-2,4,10-trione

Guidance literature:: Multi-step reaction with 2 steps

1: 90 percent / Pd(OAc)2; Ph₃P; Et₃N / acetonitrile / 12.5 h / 60 - 80 °C

2: 70 percent / MeOH / 6 h / Heating

With methanol; palladium diacetate; triethylamine; triphenylphosphine; In acetonitrile; 1: Heck coupling;
DOI:10.1021/jm0102349