(5E)-2-((2R,E)-aziridin-2-ylmethylene)-8-(tert-butyldiphenylsilanyloxy)oct-5-enoic acid methyl ester

Base Information

Chemical Name:(5E)-2-((2R,E)-aziridin-2-ylmethylene)-8-(tert-butyldiphenylsilanyloxy)oct-5-enoic acid methyl ester
CAS No.:939054-95-2
Molecular Formula:C₂₈H₃₇NO₃Si
Molecular Weight:463.692
Hs Code.:

Synonyms:(5E)-2-((2R,E)-aziridin-2-ylmethylene)-8-(tert-butyldiphenylsilanyloxy)oct-5-enoic acid methyl ester

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Chemical Property of (5E)-2-((2R,E)-aziridin-2-ylmethylene)-8-(tert-butyldiphenylsilanyloxy)oct-5-enoic acid methyl ester

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Technology Process of (5E)-2-((2R,E)-aziridin-2-ylmethylene)-8-(tert-butyldiphenylsilanyloxy)oct-5-enoic acid methyl ester

There total 3 articles about (5E)-2-((2R,E)-aziridin-2-ylmethylene)-8-(tert-butyldiphenylsilanyloxy)oct-5-enoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 939054-94-1
(5E)-8-(tert-butyldiphenylsilanyloxy)-2-((2R,E)-1-tritylaziridin-2-ylmethylene)oct-5-enoic acid methyl ester

: 939054-95-2
(5E)-2-((2R,E)-aziridin-2-ylmethylene)-8-(tert-butyldiphenylsilanyloxy)oct-5-enoic acid methyl ester

Guidance literature:: With triethylsilane; trifluoroacetic acid; In dichloromethane; at 0 ℃; for 0.333333h;
DOI:10.1021/jo070144x

Reference yield:

: 939054-89-4
(5E)-8-(tert-butyldiphenylsilanyloxy)-2-(diethoxyphosphoryl)oct-5-enoic acid methyl ester

: 939054-95-2
(5E)-2-((2R,E)-aziridin-2-ylmethylene)-8-(tert-butyldiphenylsilanyloxy)oct-5-enoic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 85 percent / Ba(OH)2 / tetrahydrofuran; H₂O / 5 h / 20 °C

2: 86 percent / Et₃SiH; trifluoroacetic acid / CH₂Cl₂ / 0.33 h / 0 °C

With triethylsilane; barium dihydroxide; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; water; 1: Horner-Wadsworth-Emmons reaction;
DOI:10.1021/jo070144x

Reference yield:

: 263365-58-8
tert-butyl(6-iodohex-3-enyloxy)diphenylsilane

: 939054-95-2
(5E)-2-((2R,E)-aziridin-2-ylmethylene)-8-(tert-butyldiphenylsilanyloxy)oct-5-enoic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 91 percent / NaH / dimethylformamide / 3 h / 60 °C

2: 85 percent / Ba(OH)2 / tetrahydrofuran; H₂O / 5 h / 20 °C

3: 86 percent / Et₃SiH; trifluoroacetic acid / CH₂Cl₂ / 0.33 h / 0 °C

With triethylsilane; barium dihydroxide; sodium hydride; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; 2: Horner-Wadsworth-Emmons reaction;
DOI:10.1021/jo070144x