5-((4-(benzyloxy)benzyl)(4H-1,2,4-triazol-4-yl)amino)biphenyl-2-carbonitrile

Base Information

Chemical Name:5-((4-(benzyloxy)benzyl)(4H-1,2,4-triazol-4-yl)amino)biphenyl-2-carbonitrile
CAS No.:1260389-64-7
Molecular Formula:C₂₉H₂₃N₅O
Molecular Weight:457.535
Hs Code.:

Synonyms:5-((4-(benzyloxy)benzyl)(4H-1,2,4-triazol-4-yl)amino)biphenyl-2-carbonitrile

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Chemical Property of 5-((4-(benzyloxy)benzyl)(4H-1,2,4-triazol-4-yl)amino)biphenyl-2-carbonitrile

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Technology Process of 5-((4-(benzyloxy)benzyl)(4H-1,2,4-triazol-4-yl)amino)biphenyl-2-carbonitrile

There total 3 articles about 5-((4-(benzyloxy)benzyl)(4H-1,2,4-triazol-4-yl)amino)biphenyl-2-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

: 1260389-63-6
4-((4-(benzyloxy)benzyl)(4H-1,2,4-triazol-4-yl)amino)-2-bromo-benzonitrile

: 98-80-6
phenylboronic acid

: 1260389-64-7
5-((4-(benzyloxy)benzyl)(4H-1,2,4-triazol-4-yl)amino)biphenyl-2-carbonitrile

Guidance literature:: With sodium carbonate; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In 1,2-dimethoxyethane; water; for 4h; Heating; Reflux; Inert atmosphere;

Reference yield:

: 36282-26-5
2-bromo-4-fluorobenzonitrile

: 1260389-64-7
5-((4-(benzyloxy)benzyl)(4H-1,2,4-triazol-4-yl)amino)biphenyl-2-carbonitrile

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium tert-butylate / dimethyl sulfoxide / 0.5 h / 20 °C

1.2: 1 h / 20 °C

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 20 °C

2.2: 18 h / 20 °C

3.1: sodium carbonate / bis(dibenzylideneacetone)-palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 4 h / Heating; Reflux; Inert atmosphere

With potassium tert-butylate; sodium hydride; sodium carbonate; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In 1,2-dimethoxyethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 1260389-62-5
4-(4H-1,2,4-triazol-4-ylamino)-2-bromo-benzonitrile

: 1260389-64-7
5-((4-(benzyloxy)benzyl)(4H-1,2,4-triazol-4-yl)amino)biphenyl-2-carbonitrile

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 20 °C

1.2: 18 h / 20 °C

2.1: sodium carbonate / bis(dibenzylideneacetone)-palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 4 h / Heating; Reflux; Inert atmosphere

With sodium hydride; sodium carbonate; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In 1,2-dimethoxyethane; water; N,N-dimethyl-formamide; mineral oil;