4-(((6-cyanobiphenyl-3-yl)(4H-1,2,4-triazol-4-yl)amino)methyl)phenyl sulfamate

Base Information

Chemical Name:4-(((6-cyanobiphenyl-3-yl)(4H-1,2,4-triazol-4-yl)amino)methyl)phenyl sulfamate
CAS No.:1260389-36-3
Molecular Formula:C₂₂H₁₈N₆O₃S
Molecular Weight:446.489
Hs Code.:

Synonyms:4-(((6-cyanobiphenyl-3-yl)(4H-1,2,4-triazol-4-yl)amino)methyl)phenyl sulfamate

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Chemical Property of 4-(((6-cyanobiphenyl-3-yl)(4H-1,2,4-triazol-4-yl)amino)methyl)phenyl sulfamate

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Technology Process of 4-(((6-cyanobiphenyl-3-yl)(4H-1,2,4-triazol-4-yl)amino)methyl)phenyl sulfamate

There total 5 articles about 4-(((6-cyanobiphenyl-3-yl)(4H-1,2,4-triazol-4-yl)amino)methyl)phenyl sulfamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 1260389-65-8
5-((4-hydroxy-benzyl)(4H-1,2,4-triazol-4-yl)amino)biphenyl-2-carbonitrile

: 1260389-36-3
4-(((6-cyanobiphenyl-3-yl)(4H-1,2,4-triazol-4-yl)amino)methyl)phenyl sulfamate

Guidance literature:: With sulphamoyl chloride; In N,N-dimethyl acetamide; at 0 - 20 ℃;

Reference yield:

: 36282-26-5
2-bromo-4-fluorobenzonitrile

: 1260389-36-3
4-(((6-cyanobiphenyl-3-yl)(4H-1,2,4-triazol-4-yl)amino)methyl)phenyl sulfamate

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium tert-butylate / dimethyl sulfoxide / 0.5 h / 20 °C

1.2: 1 h / 20 °C

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 20 °C

2.2: 18 h / 20 °C

3.1: sodium carbonate / bis(dibenzylideneacetone)-palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 4 h / Heating; Reflux; Inert atmosphere

4.1: hydrogen / 10% palladium on activated charcoal / tetrahydrofuran; methanol / 18 h

5.1: sulphamoyl chloride / N,N-dimethyl acetamide / 0 - 20 °C

With sulphamoyl chloride; potassium tert-butylate; hydrogen; sodium hydride; sodium carbonate; 10% palladium on activated charcoal; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; N,N-dimethyl acetamide; water; dimethyl sulfoxide; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 1260389-64-7
5-((4-(benzyloxy)benzyl)(4H-1,2,4-triazol-4-yl)amino)biphenyl-2-carbonitrile

: 1260389-36-3
4-(((6-cyanobiphenyl-3-yl)(4H-1,2,4-triazol-4-yl)amino)methyl)phenyl sulfamate

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogen / 10% palladium on activated charcoal / tetrahydrofuran; methanol / 18 h

2: sulphamoyl chloride / N,N-dimethyl acetamide / 0 - 20 °C

With sulphamoyl chloride; hydrogen; 10% palladium on activated charcoal; In tetrahydrofuran; methanol; N,N-dimethyl acetamide;