4-(3-(benzyloxycarbonylamino)-2-methylphenyl)-7-((2-(trimethylsilyl)ethoxy)carbonylamino)-9H-pyrido[3,4-b]indole-1-carboxamide

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Chemical Name:4-(3-(benzyloxycarbonylamino)-2-methylphenyl)-7-((2-(trimethylsilyl)ethoxy)carbonylamino)-9H-pyrido[3,4-b]indole-1-carboxamide
CAS No.:1352835-70-1
Molecular Formula:C₃₃H₃₅N₅O₅Si
Molecular Weight:609.757
Hs Code.:

Synonyms:4-(3-(benzyloxycarbonylamino)-2-methylphenyl)-7-((2-(trimethylsilyl)ethoxy)carbonylamino)-9H-pyrido[3,4-b]indole-1-carboxamide

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Chemical Property of 4-(3-(benzyloxycarbonylamino)-2-methylphenyl)-7-((2-(trimethylsilyl)ethoxy)carbonylamino)-9H-pyrido[3,4-b]indole-1-carboxamide

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Technology Process of 4-(3-(benzyloxycarbonylamino)-2-methylphenyl)-7-((2-(trimethylsilyl)ethoxy)carbonylamino)-9H-pyrido[3,4-b]indole-1-carboxamide

There total 12 articles about 4-(3-(benzyloxycarbonylamino)-2-methylphenyl)-7-((2-(trimethylsilyl)ethoxy)carbonylamino)-9H-pyrido[3,4-b]indole-1-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 1352835-69-8
4-(3-(benzyloxycarbonylamino)-2-methylphenyl)-7-((2-(trimethylsilyl)ethoxy)carbonylamino)-9H-pyrido[3,4-b]indole-1-carboxylic acid

: 1352835-70-1
4-(3-(benzyloxycarbonylamino)-2-methylphenyl)-7-((2-(trimethylsilyl)ethoxy)carbonylamino)-9H-pyrido[3,4-b]indole-1-carboxamide

Guidance literature:: With 4-methyl-morpholine; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; ammonium chloride; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; for 2.5h;

Reference yield:

: 5318-27-4
6-amino-1H-indole

: 1352835-70-1
4-(3-(benzyloxycarbonylamino)-2-methylphenyl)-7-((2-(trimethylsilyl)ethoxy)carbonylamino)-9H-pyrido[3,4-b]indole-1-carboxamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: N-ethyl-N,N-diisopropylamine / 1,4-dioxane / Inert atmosphere

2.1: 6.5 h / 115 °C

3.1: zinc; ammonium chloride / tetrahydrofuran; methanol / 5.25 h / Inert atmosphere

4.1: hydrogenchloride / toluene; 1,4-dioxane / 16 h / 20 °C / Inert atmosphere

4.2: 6.5 h / 115 °C

5.1: water; lithium hydroxide monohydrate / tetrahydrofuran; methanol / 1 h

5.2: pH ~ 5

6.1: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; 4-methyl-morpholine; ammonium chloride / N,N-dimethyl-formamide / 2.5 h

With 4-methyl-morpholine; hydrogenchloride; lithium hydroxide monohydrate; water; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; ammonium chloride; N-ethyl-N,N-diisopropylamine; zinc; In tetrahydrofuran; 1,4-dioxane; methanol; N,N-dimethyl-formamide; toluene;

Reference yield:

: 78269-85-9
carbonic acid 2,5-dioxo-pyrrolidin-1-yl ester 2-(trimethylsilanyl)-ethyl ester

: 1352835-70-1
4-(3-(benzyloxycarbonylamino)-2-methylphenyl)-7-((2-(trimethylsilyl)ethoxy)carbonylamino)-9H-pyrido[3,4-b]indole-1-carboxamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: N-ethyl-N,N-diisopropylamine / 1,4-dioxane / Inert atmosphere

2.1: 6.5 h / 115 °C

3.1: zinc; ammonium chloride / tetrahydrofuran; methanol / 5.25 h / Inert atmosphere

4.1: hydrogenchloride / toluene; 1,4-dioxane / 16 h / 20 °C / Inert atmosphere

4.2: 6.5 h / 115 °C

5.1: water; lithium hydroxide monohydrate / tetrahydrofuran; methanol / 1 h

5.2: pH ~ 5

6.1: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; 4-methyl-morpholine; ammonium chloride / N,N-dimethyl-formamide / 2.5 h

With 4-methyl-morpholine; hydrogenchloride; lithium hydroxide monohydrate; water; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; ammonium chloride; N-ethyl-N,N-diisopropylamine; zinc; In tetrahydrofuran; 1,4-dioxane; methanol; N,N-dimethyl-formamide; toluene;