methyl [4-(6-chloro-3'-ethyl-2-biphenylyl)-4-hydroxy-4-((3R)-1-{[4-({methyl[(2-nitrophenyl)sulfonyl]amino}methyl)-1-piperidinyl]carbonyl}-3-piperidinyl)butyl]carbamate

Base Information

Chemical Name:methyl [4-(6-chloro-3'-ethyl-2-biphenylyl)-4-hydroxy-4-((3R)-1-{[4-({methyl[(2-nitrophenyl)sulfonyl]amino}methyl)-1-piperidinyl]carbonyl}-3-piperidinyl)butyl]carbamate
CAS No.:1071867-03-2
Molecular Formula:C₃₉H₅₀ClN₅O₈S
Molecular Weight:784.374
Hs Code.:

methyl [4-(6-chloro-3'-ethyl-2-biphenylyl)-4-hydroxy-4-((3R)-1-{[4-({methyl[(2-nitrophenyl)sulfonyl]amino}methyl)-1-piperidinyl]carbonyl}-3-piperidinyl)butyl]carbamate

Synonyms:methyl [4-(6-chloro-3'-ethyl-2-biphenylyl)-4-hydroxy-4-((3R)-1-{[4-({methyl[(2-nitrophenyl)sulfonyl]amino}methyl)-1-piperidinyl]carbonyl}-3-piperidinyl)butyl]carbamate

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Chemical Property of methyl [4-(6-chloro-3'-ethyl-2-biphenylyl)-4-hydroxy-4-((3R)-1-{[4-({methyl[(2-nitrophenyl)sulfonyl]amino}methyl)-1-piperidinyl]carbonyl}-3-piperidinyl)butyl]carbamate

Chemical Property:

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Technology Process of methyl [4-(6-chloro-3'-ethyl-2-biphenylyl)-4-hydroxy-4-((3R)-1-{[4-({methyl[(2-nitrophenyl)sulfonyl]amino}methyl)-1-piperidinyl]carbonyl}-3-piperidinyl)butyl]carbamate

There total 5 articles about methyl [4-(6-chloro-3'-ethyl-2-biphenylyl)-4-hydroxy-4-((3R)-1-{[4-({methyl[(2-nitrophenyl)sulfonyl]amino}methyl)-1-piperidinyl]carbonyl}-3-piperidinyl)butyl]carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1071866-99-3
methyl [4-(6-chloro-3'-ethyl-2-biphenylyl)-4-hydroxy-4-((3R)-1-{[4-({[(2-nitrophenyl)sulfonyl]amino}methyl)-1-piperidinyl]carbonyl}-3-piperidinyl)butyl]carbamate

: 74-88-4
methyl iodide

: 1071867-03-2
methyl [4-(6-chloro-3'-ethyl-2-biphenylyl)-4-hydroxy-4-((3R)-1-{[4-({methyl[(2-nitrophenyl)sulfonyl]amino}methyl)-1-piperidinyl]carbonyl}-3-piperidinyl)butyl]carbamate

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 25 ℃;

Reference yield:

: 135632-53-0
tert-butyl N-(4-piperidinylmethyl)carbamate

: 1071867-03-2
methyl [4-(6-chloro-3'-ethyl-2-biphenylyl)-4-hydroxy-4-((3R)-1-{[4-({methyl[(2-nitrophenyl)sulfonyl]amino}methyl)-1-piperidinyl]carbonyl}-3-piperidinyl)butyl]carbamate

Guidance literature:: Multi-step reaction with 5 steps

1.1: triethylamine / dichloromethane / 60 h / 25 °C

2.1: acetonitrile

3.1: acetonitrile / 1 h / 50 °C

3.2: 25 °C

4.1: triethylamine / dichloromethane / 0.75 h / 0 °C

5.1: potassium carbonate / N,N-dimethyl-formamide / 25 °C

With potassium carbonate; triethylamine; In dichloromethane; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 1071866-98-2
1-({4-[({[(1,1-dimethylethyl)oxy]carbonyl}amino)methyl]-1-piperidinyl}carbonyl)-3-methyl-1H-imidazol-3-ium

: 1071867-03-2
methyl [4-(6-chloro-3'-ethyl-2-biphenylyl)-4-hydroxy-4-((3R)-1-{[4-({methyl[(2-nitrophenyl)sulfonyl]amino}methyl)-1-piperidinyl]carbonyl}-3-piperidinyl)butyl]carbamate

Guidance literature:: Multi-step reaction with 3 steps

1.1: acetonitrile / 1 h / 50 °C

1.2: 25 °C

2.1: triethylamine / dichloromethane / 0.75 h / 0 °C

3.1: potassium carbonate / N,N-dimethyl-formamide / 25 °C

With potassium carbonate; triethylamine; In dichloromethane; N,N-dimethyl-formamide; acetonitrile;