(R,S)-N-(tert-butyloxycarbonyl)-L-tyrosyl-D-alanylglycine 1,3-dimethylbutyl amide

Base Information

Chemical Name:(R,S)-N-(tert-butyloxycarbonyl)-L-tyrosyl-D-alanylglycine 1,3-dimethylbutyl amide
CAS No.:78537-08-3
Molecular Formula:C₂₅H₄₀N₄O₆
Molecular Weight:492.616
Hs Code.:

Synonyms:(R,S)-N-(tert-butyloxycarbonyl)-L-tyrosyl-D-alanylglycine 1,3-dimethylbutyl amide

Suppliers and Price of (R,S)-N-(tert-butyloxycarbonyl)-L-tyrosyl-D-alanylglycine 1,3-dimethylbutyl amide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 1 raw suppliers

Chemical Property of (R,S)-N-(tert-butyloxycarbonyl)-L-tyrosyl-D-alanylglycine 1,3-dimethylbutyl amide

Chemical Property:

Purity/Quality:: 99% ^*data from raw suppliers

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Technology Process of (R,S)-N-(tert-butyloxycarbonyl)-L-tyrosyl-D-alanylglycine 1,3-dimethylbutyl amide

There total 4 articles about (R,S)-N-(tert-butyloxycarbonyl)-L-tyrosyl-D-alanylglycine 1,3-dimethylbutyl amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 15761-50-9,34017-11-3,54548-48-0,108-09-8
2-amino-4-methylpentane

: 78537-07-2
N-(tert-butyloxycarbonyl)-L-tyrosyl-D-alanylglycine methyl ester

: 78537-08-3
(R,S)-N-(tert-butyloxycarbonyl)-L-tyrosyl-D-alanylglycine 1,3-dimethylbutyl amide

Guidance literature:: In tetrahydrofuran; chloroform; for 168h; Ambient temperature;
DOI:10.1021/jm00142a002

Reference yield:

: 3978-80-1
Boc-Tyr-OH

: 78537-08-3
(R,S)-N-(tert-butyloxycarbonyl)-L-tyrosyl-D-alanylglycine 1,3-dimethylbutyl amide

Guidance literature:: Multi-step reaction with 4 steps

1: 95 percent / triethylamine, 1-hydroxybenzotriazole (HOBT), dicyclohexylcarbodiimide (DCC) / tetrahydrofuran; CHCl₃ / Ambient temperature

2: 93 percent / 1 N NaOH / methanol / a) 0 deg C, 1 h, b) RT, 4 h

3: 70 percent / triethylamine, 1-hydroxybenzotriazole (HOBT), dicyclohexylcarbodiimide (DCC) / tetrahydrofuran; CHCl₃ / 1.) 0 deg C, 1 h, 2.) RT, 20 h

4: 98 percent / tetrahydrofuran; CHCl₃ / 168 h / Ambient temperature

With sodium hydroxide; benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; In tetrahydrofuran; methanol; chloroform;
DOI:10.1021/jm00142a002

Reference yield:

: 71591-34-9
N-(tert-butyloxycarbonyl)-L-tyrosyl-D-alanine

: 78537-08-3
(R,S)-N-(tert-butyloxycarbonyl)-L-tyrosyl-D-alanylglycine 1,3-dimethylbutyl amide

Guidance literature:: Multi-step reaction with 2 steps

1: 70 percent / triethylamine, 1-hydroxybenzotriazole (HOBT), dicyclohexylcarbodiimide (DCC) / tetrahydrofuran; CHCl₃ / 1.) 0 deg C, 1 h, 2.) RT, 20 h

2: 98 percent / tetrahydrofuran; CHCl₃ / 168 h / Ambient temperature

With benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; In tetrahydrofuran; chloroform;
DOI:10.1021/jm00142a002