(R)-N-((R)-4-(allyloxy)-2-(5-bromo-2-fluorophenyl)-3,3-difluoro-4-methylpentan-2-yl)-2-methylpropane-2-sulfinamide

Base Information

Chemical Name:(R)-N-((R)-4-(allyloxy)-2-(5-bromo-2-fluorophenyl)-3,3-difluoro-4-methylpentan-2-yl)-2-methylpropane-2-sulfinamide
CAS No.:1346146-26-6
Molecular Formula:C₁₉H₂₇BrF₃NO₂S
Molecular Weight:470.394
Hs Code.:

Synonyms:(R)-N-((R)-4-(allyloxy)-2-(5-bromo-2-fluorophenyl)-3,3-difluoro-4-methylpentan-2-yl)-2-methylpropane-2-sulfinamide

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Chemical Property of (R)-N-((R)-4-(allyloxy)-2-(5-bromo-2-fluorophenyl)-3,3-difluoro-4-methylpentan-2-yl)-2-methylpropane-2-sulfinamide

Chemical Property:

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Technology Process of (R)-N-((R)-4-(allyloxy)-2-(5-bromo-2-fluorophenyl)-3,3-difluoro-4-methylpentan-2-yl)-2-methylpropane-2-sulfinamide

There total 4 articles about (R)-N-((R)-4-(allyloxy)-2-(5-bromo-2-fluorophenyl)-3,3-difluoro-4-methylpentan-2-yl)-2-methylpropane-2-sulfinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 1310350-06-1
(R)-2-methyl-propane-2-sulfinic acid [(R)-1-(5-bromo-2-fluoro-phenyl)-2,2-difluoro-3-hydroxy-1,3-dimethyl-butyl]-amide

: 70122-89-3
tert-butyl allyl carbonate

: 1346146-26-6
(R)-N-((R)-4-(allyloxy)-2-(5-bromo-2-fluorophenyl)-3,3-difluoro-4-methylpentan-2-yl)-2-methylpropane-2-sulfinamide

Guidance literature:: tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; at 70 ℃; for 8h; Inert atmosphere;

Reference yield:

: 1310349-83-7
(R)-3-(5-bromo-2-fluoro-phenyl)-2,2-difluoro-3-((R)-2-methyl-propane-2-sulfinylamino)-butyric acid ethyl ester

: 1346146-26-6
(R)-N-((R)-4-(allyloxy)-2-(5-bromo-2-fluorophenyl)-3,3-difluoro-4-methylpentan-2-yl)-2-methylpropane-2-sulfinamide

Guidance literature:: Multi-step reaction with 2 steps

1: tetrahydrofuran; 2-methyltetrahydrofuran; (R)-N-((R)-2-(5-bromo-2,4-difluorophenyl)-3,3-difluoro-4-hydroxy-4-methylpentan-2-yl)-2-methylpropane-2-sulfinamide / 18 h / -78 - 23 °C

2: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / tetrahydrofuran / 8 h / 23 - 70 °C / Inert atmosphere

tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 2-methyltetrahydrofuran; (R)-N-((R)-2-(5-bromo-2,4-difluorophenyl)-3,3-difluoro-4-hydroxy-4-methylpentan-2-yl)-2-methylpropane-2-sulfinamide; 1: Grignard Reaction;

Reference yield:

: 198477-89-3
1-(5-bromo-2-fluorophenyl)ethan-1-one

: 1346146-26-6
(R)-N-((R)-4-(allyloxy)-2-(5-bromo-2-fluorophenyl)-3,3-difluoro-4-methylpentan-2-yl)-2-methylpropane-2-sulfinamide

Guidance literature:: Multi-step reaction with 4 steps

1: titanium(IV) tetraethanolate / tetrahydrofuran / 5 h / Reflux

2: zinc / tetrahydrofuran / 5 h / Inert atmosphere; Reflux

3: tetrahydrofuran; 2-methyltetrahydrofuran / 18 h / -78 - 23 °C

4: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / tetrahydrofuran / 8 h / 23 - 70 °C / Inert atmosphere

With titanium(IV) tetraethanolate; zinc; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 2-methyltetrahydrofuran; 2: Reformatsky Reaction;