(R)-ethyl 2-(4-amino-4-(5-bromo-2-fluorophenyl)-3,3-difluoro-2-methylpentan-2-yloxy)acetate

Base Information

Chemical Name:(R)-ethyl 2-(4-amino-4-(5-bromo-2-fluorophenyl)-3,3-difluoro-2-methylpentan-2-yloxy)acetate
CAS No.:1346146-05-1
Molecular Formula:C₁₆H₂₁BrF₃NO₃
Molecular Weight:412.247
Hs Code.:

Synonyms:(R)-ethyl 2-(4-amino-4-(5-bromo-2-fluorophenyl)-3,3-difluoro-2-methylpentan-2-yloxy)acetate

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Chemical Property of (R)-ethyl 2-(4-amino-4-(5-bromo-2-fluorophenyl)-3,3-difluoro-2-methylpentan-2-yloxy)acetate

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Technology Process of (R)-ethyl 2-(4-amino-4-(5-bromo-2-fluorophenyl)-3,3-difluoro-2-methylpentan-2-yloxy)acetate

There total 8 articles about (R)-ethyl 2-(4-amino-4-(5-bromo-2-fluorophenyl)-3,3-difluoro-2-methylpentan-2-yloxy)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.5%

: 1346146-30-2
(R)-ethyl 2-(4-(5-bromo-2-fluorophenyl)-4-(1,1-dimethylethylsulfonamido)-3,3-difluoro-2-methylpentan-2-yloxy)acetate

: 1346146-05-1
(R)-ethyl 2-(4-amino-4-(5-bromo-2-fluorophenyl)-3,3-difluoro-2-methylpentan-2-yloxy)acetate

Guidance literature:: (R)-ethyl 2-(4-(5-bromo-2-fluorophenyl)-4-(1,1-dimethylethylsulfonamido)-3,3-difluoro-2-methylpentan-2-yloxy)acetate; With trifluorormethanesulfonic acid; In dichloromethane; at 0 - 23 ℃; for 0.5h;

With sodium hydrogencarbonate; In dichloromethane;

Reference yield: 88.5%

: 1346146-05-1
(R)-ethyl 2-(4-amino-4-(5-bromo-2-fluorophenyl)-3,3-difluoro-2-methylpentan-2-yloxy)acetate

Guidance literature:

Reference yield:

: 1310349-83-7
(R)-3-(5-bromo-2-fluoro-phenyl)-2,2-difluoro-3-((R)-2-methyl-propane-2-sulfinylamino)-butyric acid ethyl ester

: 1346146-05-1
(R)-ethyl 2-(4-amino-4-(5-bromo-2-fluorophenyl)-3,3-difluoro-2-methylpentan-2-yloxy)acetate

Guidance literature:: Multi-step reaction with 5 steps

1: tetrahydrofuran; 2-methyltetrahydrofuran; (R)-N-((R)-2-(5-bromo-2,4-difluorophenyl)-3,3-difluoro-4-hydroxy-4-methylpentan-2-yl)-2-methylpropane-2-sulfinamide / 18 h / -78 - 23 °C

2: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / tetrahydrofuran / 8 h / 23 - 70 °C / Inert atmosphere

3: sodium periodate / ruthenium(III) trichloride hydrate / ethyl acetate; acetonitrile; water / 3 h / 23 °C

4: thionyl chloride / 18 h / 23 °C / Reflux

5: trifluorormethanesulfonic acid / dichloromethane / 0.5 h / 0 - 23 °C

With sodium periodate; thionyl chloride; trifluorormethanesulfonic acid; tetrakis(triphenylphosphine) palladium⁽⁰⁾; ruthenium(III) trichloride hydrate; In tetrahydrofuran; 2-methyltetrahydrofuran; dichloromethane; (R)-N-((R)-2-(5-bromo-2,4-difluorophenyl)-3,3-difluoro-4-hydroxy-4-methylpentan-2-yl)-2-methylpropane-2-sulfinamide; water; ethyl acetate; acetonitrile; 1: Grignard Reaction;