1-(2-hydroxy-3-methoxy-5-methylphenyl)-2-methoxynaphthalene

Base Information

• Chemical Name: 1-(2-hydroxy-3-methoxy-5-methylphenyl)-2-methoxynaphthalene
• CAS No.: 1219118-26-9
• Molecular Formula: C₁₉H₁₈O₃
• Molecular Weight: 294.35
• Mol file: 1219118-26-9.mol

Synonyms:1-(2-hydroxy-3-methoxy-5-methylphenyl)-2-methoxynaphthalene

Chemical Property of 1-(2-hydroxy-3-methoxy-5-methylphenyl)-2-methoxynaphthalene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of 1-(2-hydroxy-3-methoxy-5-methylphenyl)-2-methoxynaphthalene

There total 4 articles about 1-(2-hydroxy-3-methoxy-5-methylphenyl)-2-methoxynaphthalene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

2-Methoxynaphthalene (93-04-9) + 2-Methoxy-4-methylphenol (93-51-6) → 1-(2-hydroxy-3-methoxy-5-methylphenyl)-2-methoxynaphthalene (1219118-26-9)

Guidance literature:

With nitrosonium tetrafluoroborate; trifluoroacetic acid; In dichloromethane; at 0 ℃; for 1h; Sealed tube;

DOI:10.1021/acs.orglett.8b01631

Reference yield: 11.0%

2-Methoxy-4-methylphenol (93-51-6) + 1-Methoxynaphthalene (2216-69-5) → 1-(2-hydroxy-3-methoxy-5-methylphenyl)-2-methoxynaphthalene (1219118-26-9)

Guidance literature:

With selenium(IV) oxide; for 1.25h; Reflux;

Reference yield:

2-Methoxynaphthalene (93-04-9) + 6,6-Dimethoxy-4-methyl-cyclohexa-2,4-dienone (147088-65-1) → 1-(2-hydroxy-3-methoxy-5-methylphenyl)-2-methoxynaphthalene (1219118-26-9)

Guidance literature:

With boron trifluoride diethyl etherate; In dichloromethane; at -30 ℃; for 0.0166667h; regioselective reaction;

DOI:10.1021/ol401341s

upstream raw materials:

2-Methoxynaphthalene

2-Methoxy-4-methylphenol

6,6-Dimethoxy-4-methyl-cyclohexa-2,4-dienone

1-Methoxynaphthalene