(S)-tert-butyl 1-(3,5-diiodo-4-methoxyphenyl)-3-(methoxymethoxy)propan-2-ylcarbamate

Base Information

• Chemical Name: (S)-tert-butyl 1-(3,5-diiodo-4-methoxyphenyl)-3-(methoxymethoxy)propan-2-ylcarbamate
• CAS No.: 1426447-00-8
• Molecular Formula: C₁₇H₂₅I₂NO₅
• Molecular Weight: 577.198
• Mol file: 1426447-00-8.mol

Synonyms:(S)-tert-butyl 1-(3,5-diiodo-4-methoxyphenyl)-3-(methoxymethoxy)propan-2-ylcarbamate

Chemical Property of (S)-tert-butyl 1-(3,5-diiodo-4-methoxyphenyl)-3-(methoxymethoxy)propan-2-ylcarbamate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-tert-butyl 1-(3,5-diiodo-4-methoxyphenyl)-3-(methoxymethoxy)propan-2-ylcarbamate

There total 4 articles about (S)-tert-butyl 1-(3,5-diiodo-4-methoxyphenyl)-3-(methoxymethoxy)propan-2-ylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

(S)-tert-butyl 1-(3,5-diiodo-4-methoxyphenyl)-3-hydroxypropan-2-ylcarbamate (1423720-70-0) + chloromethyl methyl ether (107-30-2) → (S)-tert-butyl 1-(3,5-diiodo-4-methoxyphenyl)-3-(methoxymethoxy)propan-2-ylcarbamate (1426447-00-8)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 - 20 ℃; for 10h; Inert atmosphere;

DOI:10.1016/j.tet.2013.02.079

Reference yield:

3,5-diiodo-l-tyrosine (300-39-0) → (S)-tert-butyl 1-(3,5-diiodo-4-methoxyphenyl)-3-(methoxymethoxy)propan-2-ylcarbamate (1426447-00-8)

Guidance literature:

Multi-step reaction with 4 steps

1: sodium hydrogencarbonate / methanol; water / 20 °C

2: potassium carbonate / acetonitrile / 5 h / 60 °C

3: lithium borohydride / tetrahydrofuran / 20 °C / Inert atmosphere

4: N-ethyl-N,N-diisopropylamine / dichloromethane / 10 h / 0 - 20 °C / Inert atmosphere

With lithium borohydride; sodium hydrogencarbonate; potassium carbonate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; dichloromethane; water; acetonitrile;

DOI:10.1016/j.tet.2013.02.079

Reference yield:

(tert-butoxycarbonyl)-3,5-diiodotyrosine (62129-53-7,1260011-49-1,214630-08-7) → (S)-tert-butyl 1-(3,5-diiodo-4-methoxyphenyl)-3-(methoxymethoxy)propan-2-ylcarbamate (1426447-00-8)

Guidance literature:

Multi-step reaction with 3 steps

1: potassium carbonate / acetonitrile / 5 h / 60 °C

2: lithium borohydride / tetrahydrofuran / 20 °C / Inert atmosphere

3: N-ethyl-N,N-diisopropylamine / dichloromethane / 10 h / 0 - 20 °C / Inert atmosphere

With lithium borohydride; potassium carbonate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane; acetonitrile;

DOI:10.1016/j.tet.2013.02.079

upstream raw materials:

(S)-tert-butyl 1-(3,5-diiodo-4-methoxyphenyl)-3-hydroxypropan-2-ylcarbamate

chloromethyl methyl ether

3,5-diiodo-l-tyrosine

(tert-butoxycarbonyl)-3,5-diiodotyrosine

Downstream raw materials:

C₁₇H₂₇NO₇

C₁₇H₂₇NO₆