(2S)-2-azaniumyl-3-(4-hydroxy-3,5-diiodophenyl)propanoate

Base Information

Chemical Name:(2S)-2-azaniumyl-3-(4-hydroxy-3,5-diiodophenyl)propanoate
CAS No.:300-39-0
Molecular Formula:C9H9I2NO3
Molecular Weight:432.984
Hs Code.:29225090
Mol file:300-39-0.mol

Synonyms:(2S)-2-azaniumyl-3-(4-hydroxy-3,5-diiodophenyl)propanoate

Suppliers and Price of (2S)-2-azaniumyl-3-(4-hydroxy-3,5-diiodophenyl)propanoate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
3,5-Diiodo-L-tyrosine
25g
$ 185.00

TRC
3,5-Diiodo-L-tyrosine
5g
$ 85.00

Sigma-Aldrich
3,5-Diiodo-L-tyrosine dihydrate crystalline
10 g
$ 77.20

Medical Isotopes, Inc.
3,5-Diiodo-L-tyrosine
5 g
$ 370.00

Matrix Scientific
3,5-Diiodo-L-tyrosine 95+%
10g
$ 59.00

Matrix Scientific
3,5-Diiodo-L-tyrosine 95+%
5g
$ 38.00

Matrix Scientific
3,5-Diiodo-L-tyrosine 95+%
100g
$ 301.00

Iris Biotech GmbH
H-L-Tyr(3,5-I2)-OH*2H2O
100 g
$ 303.75

Iris Biotech GmbH
H-L-Tyr(3,5-I2)-OH*2H2O
250 g
$ 506.25

Iris Biotech GmbH
H-L-Tyr(3,5-I2)-OH*2H2O
1 kg
$ 1282.50

Total 133 raw suppliers

Chemical Property of (2S)-2-azaniumyl-3-(4-hydroxy-3,5-diiodophenyl)propanoate

Chemical Property:

Appearance/Colour:white to beige powder
Vapor Pressure:1.78E-07mmHg at 25°C
Melting Point:200°C (dec.)(lit.)
Refractive Index:1.2 ° (C=5, 1mol/L HCl)
Boiling Point:410.5 °C at 760 mmHg
PKA:2.12(at 25℃)
Flash Point:202.1 °C
PSA：102.01000
Density:2.405 g/cm³
LogP:2.12750
Storage Temp.:2-8°C
Sensitive.:Light Sensitive
Solubility.:Aqueous Acid (Slightly), DMSO (Slightly)
Water Solubility.:slightly soluble
XLogP3:0.2
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:2
Exact Mass:432.86719
Heavy Atom Count:15
Complexity:222

Purity/Quality:

99%, ^*data from raw suppliers

3,5-Diiodo-L-tyrosine ^*data from reagent suppliers

Safty Information:

Pictogram(s): R36/37/38:;
Hazard Codes:Xi
Statements: 36/37/38
Safety Statements: 26-37/39-36/37-24/25

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Canonical SMILES:C1=C(C=C(C(=C1I)O)I)CC(C(=O)[O-])[NH3+]
Isomeric SMILES:C1=C(C=C(C(=C1I)O)I)C[C@@H](C(=O)[O-])[NH3+]
Description Diiodotyrosine does not possess pronounced hormonal activity. However, it stops production of thyrotropic hormone by the anterior lobe of the hypophysis, which activates thyroid gland activity.
Uses It is used for hyperthyroid forms of endemic and sporadic goiters, diffuse, toxic goiters, and other illnesses accompanied by thyrotoxicity. 3,5-Diiodo-L-tyrosine is a reactant used in the synthesis of fluorescent unnatural amino acids bearing stilbene or vinylene backbones. Also used in the discovery of potent heterodimeric antagonists of inhibitor of Apoptosis proteins with prolonged anti-tumor activity.

Technology Process of (2S)-2-azaniumyl-3-(4-hydroxy-3,5-diiodophenyl)propanoate

There total 5 articles about (2S)-2-azaniumyl-3-(4-hydroxy-3,5-diiodophenyl)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.63%

: 60-18-4,18875-48-4,25619-78-7,30704-25-7
L-tyrosine

: 300-39-0
3,5-diiodo-l-tyrosine

Guidance literature:: With hydrogen iodide; acetic acid; In dimethyl sulfoxide; at 65 ℃; for 0.025h;
DOI:10.1039/c8nj04385j

Reference yield: 32.6%

: 60-18-4,18875-48-4,25619-78-7,30704-25-7
L-tyrosine

: 300-39-0
3,5-diiodo-l-tyrosine

: 70-78-0
3-Iodo-L-tyrosine

Guidance literature:: With chloroamine-T; sodium iodide; In water; at 20 ℃; for 0.00277778h; Product distribution; other reaction time, pregenerated iodine, reaction in the presence of tryptophan and Nⁱⁿ-formyl-tryptophan;

Reference yield:

: 70-78-0
3-Iodo-L-tyrosine

: 300-39-0
3,5-diiodo-l-tyrosine

Guidance literature:: With iodine; In water; at 22 ℃; for 0.0833333h; potassim iodide/chloramine T in phosphate buffer instead of iodine; tritium isotope effect;