7-chloro-3-(hydroxymethyl)-2-(4-(4-(trifluoromethoxy)phenoxy)phenyl)quinolin-4(1H)-one

Base Information

Chemical Name:7-chloro-3-(hydroxymethyl)-2-(4-(4-(trifluoromethoxy)phenoxy)phenyl)quinolin-4(1H)-one
CAS No.:1361005-39-1
Molecular Formula:C₂₃H₁₅ClF₃NO₄
Molecular Weight:461.825
Hs Code.:

Synonyms:7-chloro-3-(hydroxymethyl)-2-(4-(4-(trifluoromethoxy)phenoxy)phenyl)quinolin-4(1H)-one

Suppliers and Price of 7-chloro-3-(hydroxymethyl)-2-(4-(4-(trifluoromethoxy)phenoxy)phenyl)quinolin-4(1H)-one

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 7-chloro-3-(hydroxymethyl)-2-(4-(4-(trifluoromethoxy)phenoxy)phenyl)quinolin-4(1H)-one

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Technology Process of 7-chloro-3-(hydroxymethyl)-2-(4-(4-(trifluoromethoxy)phenoxy)phenyl)quinolin-4(1H)-one

There total 2 articles about 7-chloro-3-(hydroxymethyl)-2-(4-(4-(trifluoromethoxy)phenoxy)phenyl)quinolin-4(1H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

: 1361005-37-9
ethyl 7-chloro-4-oxo-2-(4-(4-(trifluoromethoxy)phenoxy)phenyl)-1,4-dihydroquinoline-3-carboxylate

: 1361005-39-1
7-chloro-3-(hydroxymethyl)-2-(4-(4-(trifluoromethoxy)phenoxy)phenyl)quinolin-4(1H)-one

Guidance literature:: With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 - 20 ℃; for 2h; Inert atmosphere;
DOI:10.1021/jm201179h

Reference yield:

: 40928-13-0
4-chloroisatoic anhydride

: 1361005-89-1
C₁₈H₁₅F₃O₅

: 1361005-39-1
7-chloro-3-(hydroxymethyl)-2-(4-(4-(trifluoromethoxy)phenoxy)phenyl)quinolin-4(1H)-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.25 h / 20 °C / Inert atmosphere

1.2: 16 h / Inert atmosphere; Reflux

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / 0 - 20 °C / Inert atmosphere

With lithium aluminium tetrahydride; sodium hydride; In tetrahydrofuran; N,N-dimethyl-formamide; mineral oil;
DOI:10.1021/jm201179h