ethyl 7-chloro-4-oxo-2-(4-(4-(trifluoromethoxy)phenoxy)phenyl)-1,4-dihydroquinoline-3-carboxylate

Base Information

• Chemical Name: ethyl 7-chloro-4-oxo-2-(4-(4-(trifluoromethoxy)phenoxy)phenyl)-1,4-dihydroquinoline-3-carboxylate
• CAS No.: 1361005-37-9
• Molecular Formula: C₂₅H₁₇ClF₃NO₅
• Molecular Weight: 503.862

Synonyms:ethyl 7-chloro-4-oxo-2-(4-(4-(trifluoromethoxy)phenoxy)phenyl)-1,4-dihydroquinoline-3-carboxylate

Chemical Property of ethyl 7-chloro-4-oxo-2-(4-(4-(trifluoromethoxy)phenoxy)phenyl)-1,4-dihydroquinoline-3-carboxylate

Chemical Property:

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Technology Process of ethyl 7-chloro-4-oxo-2-(4-(4-(trifluoromethoxy)phenoxy)phenyl)-1,4-dihydroquinoline-3-carboxylate

There total 2 articles about ethyl 7-chloro-4-oxo-2-(4-(4-(trifluoromethoxy)phenoxy)phenyl)-1,4-dihydroquinoline-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 30.0%

4-chloroisatoic anhydride (40928-13-0) + C18H15F3O5 (1361005-89-1) → ethyl 7-chloro-4-oxo-2-(4-(4-(trifluoromethoxy)phenoxy)phenyl)-1,4-dihydroquinoline-3-carboxylate (1361005-37-9)

Guidance literature:

C₁₈H₁₅F₃O₅; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 20 ℃; for 0.25h; Inert atmosphere;

4-chloroisatoic anhydride; In N,N-dimethyl-formamide; for 16h; Inert atmosphere; Reflux;

DOI:10.1021/jm201179h

Reference yield: 30.0%

→ ethyl 7-chloro-4-oxo-2-(4-(4-(trifluoromethoxy)phenoxy)phenyl)-1,4-dihydroquinoline-3-carboxylate (1361005-37-9)

Guidance literature:

Reference yield: 48.0%

ethyl 7-chloro-4-oxo-2-(4-(4-(trifluoromethoxy)phenoxy)phenyl)-1,4-dihydroquinoline-3-carboxylate (1361005-37-9) → 7-chloro-3-(hydroxymethyl)-2-(4-(4-(trifluoromethoxy)phenoxy)phenyl)quinolin-4(1H)-one (1361005-39-1)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 - 20 ℃; for 2h; Inert atmosphere;

DOI:10.1021/jm201179h

upstream raw materials:

4-chloroisatoic anhydride

C₁₈H₁₅F₃O₅

Downstream raw materials:

7-chloro-3-(hydroxymethyl)-2-(4-(4-(trifluoromethoxy)phenoxy)phenyl)quinolin-4(1H)-one

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