(1R,2R)-3-(tert-butyldimethylsilyloxy)-1-methylamino-1-phenylpropan-2-ol

Base Information

Chemical Name:(1R,2R)-3-(tert-butyldimethylsilyloxy)-1-methylamino-1-phenylpropan-2-ol
CAS No.:363620-51-3
Molecular Formula:C₁₆H₂₉NO₂Si
Molecular Weight:295.497
Hs Code.:

Synonyms:(1R,2R)-3-(tert-butyldimethylsilyloxy)-1-methylamino-1-phenylpropan-2-ol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (1R,2R)-3-(tert-butyldimethylsilyloxy)-1-methylamino-1-phenylpropan-2-ol

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Technology Process of (1R,2R)-3-(tert-butyldimethylsilyloxy)-1-methylamino-1-phenylpropan-2-ol

There total 1 articles about (1R,2R)-3-(tert-butyldimethylsilyloxy)-1-methylamino-1-phenylpropan-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 18162-48-6
tert-butyldimethylsilyl chloride

: 313640-98-1
(2R,3R)-3-(methylamino)-3-phenyl-1,2-propanediol

: 363620-51-3
(1R,2R)-3-(tert-butyldimethylsilyloxy)-1-methylamino-1-phenylpropan-2-ol

Guidance literature:: With 1H-imidazole; In dichloromethane; at 20 ℃; for 1.5h;
DOI:10.1016/S0957-4166(01)00228-2

Reference yield:

: 363620-51-3
(1R,2R)-3-(tert-butyldimethylsilyloxy)-1-methylamino-1-phenylpropan-2-ol

: 321-97-1,7009-81-6,90-83-5,6912-63-6
(1R,2R)-pseudoephedrine

Guidance literature:: Multi-step reaction with 6 steps

1: Ph₃P; di-iso-propyl azodicarboxylate / diethyl ether / 24 h / 20 °C

2: 1.35 g / NaI / acetone / 4 h / Heating

3: 83 percent / KF / methanol / 3 h / Heating

4: 72 percent / pyridine / 15 h

5: 76 percent / NaBH₄ / dimethylsulfoxide / 2 h / 150 °C

6: 88 percent / aq. KOH / ethanol / 2 h / Heating

With pyridine; potassium fluoride; potassium hydroxide; sodium tetrahydroborate; di-isopropyl azodicarboxylate; triphenylphosphine; sodium iodide; In methanol; diethyl ether; ethanol; dimethyl sulfoxide; acetone;
DOI:10.1016/S0957-4166(01)00228-2

Reference yield:

: 363620-51-3
(1R,2R)-3-(tert-butyldimethylsilyloxy)-1-methylamino-1-phenylpropan-2-ol

: 363620-52-4
(2R,3S)-3-(tert-butyldimethylsilyloxymethyl)-1-methyl-2-phenylazirane

Guidance literature:: With di-isopropyl azodicarboxylate; triphenylphosphine; In diethyl ether; at 20 ℃; for 24h;
DOI:10.1016/S0957-4166(01)00228-2