Merafloxacin

Base Information

Chemical Name:Merafloxacin
CAS No.:91188-00-0
Molecular Formula:C₁₉H₂₃F₂N₃O₃
Molecular Weight:379.407
Hs Code.:
UNII:G6U51T1K77
DSSTox Substance ID:DTXSID40869517
Nikkaji Number:J22.183J
Wikipedia:Merafloxacin
Wikidata:Q27278858
NCI Thesaurus Code:C83932
Metabolomics Workbench ID:144398
ChEMBL ID:CHEMBL6209
Mol file:91188-00-0.mol

Synonyms:1-ethyl-7-(3-((ethylamino)methyl)-1-pyrrolidinyl)-6,8-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid;CI 934;CI-934

Suppliers and Price of Merafloxacin

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Adipogen Life Sciences
Merafloxacin ≥95%
5 mg
$ 80.00

Total 2 raw suppliers

Chemical Property of Merafloxacin

Chemical Property:

Boiling Point:545.8°Cat760mmHg
Flash Point:283.9°C
PSA：74.57000
Density:1.304g/cm³
LogP:2.88950
XLogP3:-0.1
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:8
Rotatable Bond Count:6
Exact Mass:379.17074793
Heavy Atom Count:27
Complexity:615

Purity/Quality:

97% ^*data from raw suppliers

Merafloxacin ≥95% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCNCC1CCN(C1)C2=C(C=C3C(=C2F)N(C=C(C3=O)C(=O)O)CC)F

Technology Process of Merafloxacin

There total 5 articles about Merafloxacin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 75338-42-0
1-ethyl-6,7,8-trifluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic acid

: 91187-83-6
3-((N-ethylamino)methyl)pyrrolidine

: 91188-00-0,110013-21-3,99735-05-4
1-ethyl-7-[3-(ethylamino)methyl]-1-pyrrolidinyl-6,8-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid

Guidance literature:: In acetonitrile; at 50 - 80 ℃;
DOI:10.1021/jm00154a003

Reference yield:

: 75338-42-0
1-ethyl-6,7,8-trifluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic acid

: 91187-83-6
3-((N-ethylamino)methyl)pyrrolidine

: 6674-22-2,83329-50-4
1,8-diazabicyclo[5.4.0]undec-7-ene

: 91188-00-0,110013-21-3,99735-05-4
1-ethyl-7-[3-(ethylamino)methyl]-1-pyrrolidinyl-6,8-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid

Guidance literature:: In acetonitrile;

Reference yield:

: 100501-62-0
ethyl 1-ethyl-6,7,8-trifluoro-1,4-dihydro-4-oxoquinoline-3-carboxylate

: 91188-00-0,110013-21-3,99735-05-4
1-ethyl-7-[3-(ethylamino)methyl]-1-pyrrolidinyl-6,8-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1: HCl / acetic acid / Heating

2: 80 percent / DBU / acetonitrile / 1.) reflux, 2.5 h, 2.) room temperature, overnight

With hydrogenchloride; 1,8-diazabicyclo[5.4.0]undec-7-ene; In acetic acid; acetonitrile;
DOI:10.1021/jm00400a017